Nature solved many problems, which industrial microbiologists encounter, when establishing microbial production processes. Natural adaptation to all possible ecological niches bred microorganisms, ready to tackle many industrial tasks. Our lab takes advantage of this natural biodiversity to find cell factories, which are as best as possible suited for the conditions, required by the industrial processes. We focus on chemical production from renewable resources to contribute to the development of a carbon neutral society.
Our lab’s philosophy is to combine natures diversity with synthetic biology, to develop bio-processes as close as possible to industrial realities. We employ bacteria, yeasts and filamentous fungi of different origins. Lactic acid bacteria are among our favorites as they combine extraordinary stress resistance with high carbon flux rates and low biomass formation.
For our synthetic approaches we are focusing on membrane transport phenomena. Compartmentalization is a basic principle of life. The minimal compartment is built by the cell membrane, dividing a hostile “outside” from the living “inside”. The decision, which compounds are transported in which direction is of utmost importance for the survival of any given cell. It is also of major interest for industrial microbiologists as substrate uptake and product export are limiting factors for bio-processes. Our lab is dedicated to understand transport mechanisms better and to make use of this knowledge for bio-process development.
#FEMSmicroBlog: Citric acid transporter and 'a matter of honor'
A new paper in FEMS Yeast Research by Anna Erian identified the transporter of citric acid in the yeast Yarrowia lipolytica. Optimisation of industrial production of citric acid using yeasts is one step ahead. In this #BehindThePaper interview for the #FEMSmicroBlog, we spoke with senior author Michael Sauer who presents the significance of the paper to different audiences and tells why, sometimes, finding the right protein is a matter of honor. #FascinatingMicrobes
The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2. (2019) Gaßler, T., Sauer M., Gasser B., Egermeier M., Troyer Ch., Causon T., Hann St., Mattanovich D., Steiger M. Nature Biotechnology https://doi.org/10.1038/s41587-019-0363-0
Michael Sauer, Ass.Prof. Dipl.Natw. ETH FH-Prof. Dr.