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Research project (§ 26 & § 27)
Duration : 2019-07-01 - 2020-06-30

Mesenchymal stem cells (MSCs) are important candidates for cell-based therapies in regenerative medicine. MSCs are isolated from donor tissue and then propagated in vitro on 2D plastic surfaces. These traditional culture formats do not match the physiological in vivo situation. MSCs cultured under 3D conditions (e.g., as aggregates) show much higher therapeutic potential. Within the framework of this project, a bioprocess is being developed which enables the isolation and propagation of MSCs continuously under three-dimensional conditions. For this, donor tissue is embedded in a hydrogel, whereupon MSCs migrate from the tissue into the hydrogel. These cells are then propagated as 3D aggregates in a stirred tank bioreactor. This process avoids repetitive passenger traffic, which among other things leads to damage to the surface markers and unwanted genetic changes.
Research project (§ 26 & § 27)
Duration : 2019-04-01 - 2020-09-30

One of the main challenges of the next century is the CO2 emission reduction in a sustainable way in order to mitigate climate change. Further, the increasing food demand of the growing world population has to be covered under preservation of the diversity of natural ecosystems. Our aim is to tap CO2 as a sustainable resource in order to provide a commercial solution for the climate issue. With a novel yeast strain, CO2 can be converted into high-value biomass which is used as an animal feed additive, without using agricultural area.
Research project (§ 26 & § 27)
Duration : 2019-01-02 - 2020-01-01

The biological information derived from the microbiome can help to answer crucial questions that may arise when dealing with valuable objects. A microbial pedigree can help to: • certificate the authenticity of an object, • to identify the biological material and microbial species of an artefact, • to get insights into the geographical origin of an artefact, • to get insights into the travel history of an object and into the storage conditions, • to group objects of unknown origin, • to decipher the usage of an object. The samples for performing microbial pedigrees will be provided by the Istituto Centrale per il Restauro e la Conservazione del Patrimonio Archivistico e Librario. Up to 6 cotton swabs or membrane samples will be taken from each object and will be pooled into one microbial pedigree analysis.

Supervised Theses and Dissertations