Biopharmaceutical Technology

This competence area deals with the formulation, characterization and control of various products by biochemical and biophysical methods, as well as in-vitro and in-vivo assays. The repertoire of therapeutically interesting molecules includes biologicals from bioreactor and plants. The molecules are used to establish biodegradable carrier systems and innovative optimized formulations for different approaches:

•  Artificial membrane systems as models and assays

•  Investigation of drug transport mechanism and functionality

•  New therapy and vaccine concepts

•  Lipid based carriers for specific drug deposition

Working Groups

WG Vorauer

WG Kasper

WG Kunert

WG Steindl


Bioprocess Engineering

•         Engineering science of biological systems

•         Upstream – und Downstream processing of products produced with cellular systems

•         Bioprocess engineering uses mathematical models and simulation for design, planning,

          prediction and optimization of processes.  Model based process control combines monitoring

          technology with simulation.

•         A constant feedback with the properties of the biological system is unique for modern

          approaches in bioprocess engineering.

•        Specific methodological  platforms for  USP and DSP:

          –       USP:   Fermentation (Automation, Monitoring, Modeling),

          –       Characterizing of organisms under production conditions, identification of modification targets

          –       DSP:   Engineering and development of thermal and mechanical unit operations for

                   bioseparation purposes including small and large molecules

          –      Application and development of novel on- und off-line monitoring methods for product

                  characterization in the workflow of USP and DSP

•         Expertise and opportunity to integrate biological sciences with engineering to improve biological production
          processes.

Working Groups

Fermentation

Downstream

Umweltbiotechnologie (UBT)


Genetic Resources and Biodiversity of Plants, Fungi and Procaryotes”

•          In situ, ex-situ and in-vitro conservation of prokaryotes,
           fungi, crop plants and their pathogens

•          Phylogeny, diversity and characterization of crop plants and
           micro-organisms (cultivable and non-cultivable)

•          Ecophysiology and stress resistance in plants, fungi and
           procaryotes (genomics, proteomics)

Working groups

ACBR

AG Laimer


Molecular and Cellular Biotechnology

This competence area comprises the study, design and engineering of cells to function as cell factories, as biological models and as products.
For our purpose this also includes the design and engineering of biomolecules as the natural products of cells, focussing on:

•         recombinant protein production in bacteria, yeast, insect cells and mammalian cells

•         establishment and characterisation of primary and immortalised differentiated cells
          as producer cells, as product and as model systems for biological, aging and biomedical research

•         metabolic engineering for production of organic acids and vitamins

•         design and engineering of proteins for enhanced functionality (e.g. antibodies and antibody fragments)

•         design, engineering and selection of cells for improved performance in biotechnological processes

Working Groups

WG Borth

WG Grabherr

WG Grillari

WG Kunert

WG Mattanovich

WG Rueker


Quantitative Biology and Bioinformatics

This competence area comprises the computational analysis of biological processes. By incorporating computational approaches into biological research we aim to

  • reveal and describe cellular processes and regulatory networks
  • identify novel ways to detect biologically relevant patterns in the huge data sets available from post-genomic methods today

Both on a molecular level and on the level of whole organisms, the improved understanding gained by bioinformatics and modelling will reveal promising targets for optimisation and thus lead towards better control and increased predictability of molecular interactions and bioprocesses.

Working Groups

Chair of Bioinformatics

WG Borth

WG Grillari

WG Mattanovich