The Core Facility Bioactive Molecules: Screening and Analysis (BMoSA) provides high throughput microbiology screening ressources  and high-end mass spectrometry for small molecule as well as for polymer science.

The CF BMoSA is located at the BOKU campus in Tulln and hosted by two departments and three institutes. The laboratories of the Screening part are located at UFT while Analysis is hosted by IFA.

Covering a broad field of expertise, the CF BMoSA is mainly separated into a screening and analysis part, which can further be divided into small molecule and polymer analysis.

Boku Campus Tulln

Screening

The screening facility provides hardware and expertise for cooperation projects and contract work. Our robotic liquid handling equipment is especially adapted to perform high throughput searches for bioactive metabolites and enzymes. We further characterize the chemical and biological properties of the found substances.

  • investigate the interaction of microbes with other organisms (bacteria, fungi, algae, plant, animal cells) and to identify the production of bioactive substances (antibiotics, pharmaceuticals, bioeffectors, agroceuticals, etc.).

  • study metabolomes of microbes under a multitude of environmental and nutritional conditions to identify bio-and agro-technological potential.

  • study cells of different origin (microbes, plants, insects) in their mutual stimulatory or inhibitory effects in a high-throughput way.

  • study host-pathogen interactions or identify organic control species.

  • screen for biotech enzymes

  • perform large scale microbiology (BSL2 certified) screening experiments e.g. MIC determination

 

Contact: Christoph Schüller

Small molecules

In the small molecule analysis part we are focussing on the field of metabolomics. With the available equipment and methods primary as well as secondary metabolites can be analysed and quantified. Besides targeted analytics we have broad expertise in untargeted metabolomics studies using high resolution mass spectrometry. In recent years and projects we gained a lot of experience in the use of stable isotopes in metabolomics studies and developed various workflows for comprehensive untargeted metabolomics studies.

For analytical services we are equipped with

Additionally we offer to assist in your stable isotope labelling assisted metabolomics experiments including the possibility to grow your own labelled plant material.

 

Contact: Maria Doppler

Polymers

With a 20+ years of experience in applied polymer biotechnology, the BMoSa Polymer analysis team has a vast experience in the analysis of synthetic polymers.

The team is covering the whole “plastic cycle” spectrum, focusing in particular on three pillars:

  • polymer synthesis: analysis of synthesized aliphatic and aromatic polyesters;

  • surface functionalization: analysis of chemical changes;

  • depolymerization for recycling: analysis of the oligomers released by enzymatic treatments.


Some of the offered services you can see here.

Contact: Alessandro Pellis

[Translate to English:] Pellis at al. 2016, The closure of the cycle: enzymatic synthesis and functionalization of bio-based polyesters, Trends in biotechnology, 34 (4), 316-328. DOI: 10.1016/j.tibtech.2015.12.009

Management