The course will present the fundamentals of NMR spectroscopy and its application to structural studies of biomolecules, mainly proteins, but also nucleic acids and carbohydrates, as well as their interactions. The established methodology to obtain structural information will be described. Special emphasis will be placed in the application to study molecular recognition. Most of the course will describe applications to liquid state samples, but applications to solid state samples will also be illustrated.
The class is aimed at all types of students and researchers, and we encourage you to take it (even if you don't need the ECTs).
Prof. Blanco Gutierrez (Biological Research Centre of the Spanish National research Council-CSIC) obtained his Ph.D. in Chemistry at the Complutense University of Madrid in 1992. As a predoc at Institute of Structure of Matter-CSIC, he used NMR for the characterization of linear peptides folding into β-hairpins. As a postdoc at European Molecular Biology Laboratory (Heidelberg), he studied the structure and folding of spectrin SH3 domain, and at NIH he used solid-state NMR to study the structure of HIV-Rev protein fibers. He moved back to CSIC (Spain) in 2000 and participated in a structural genomics project determining the structure of a protein with a novel fold. He joined the Spanish National Cancer Research Centre (CNIO) in 2002 as a Ramón y Cajal research professor where he studied tumor suppressor ING4 and several meganucleases. In 2007 he moved to CIC bioGUNE as IKERBASQUE research professor to work on the structural biology of cancer using NMR and other methods. In 2020 he relocated his lab to the Biological Research Centre-CSIC in Madrid. He has authored 123 publications with more than 5000 citations, and an h-index of 40. He has supervised 9 Ph.D. Thesis, and is Honorary Professor of the Universidad Autónoma de Madrid.
Course number VO, 803015: Nuclear magnetic resonance spectroscopy for structural studies of biomolecules.
More details under: https://online.boku.ac.at/BOKUonline/pl/ui/$ctx/wbLv.wbShowLVDetail?pStpSpNr=302768
For more information, please contact: Prof. Jose L. Toca-Herrera (jose.toca-herrera(at)boku.ac.at)