802301 Biomaterial interfaces and interactions (in Eng.)

Vortragende/r (Mitwirkende/r)
Reimhult, Erik
Angeboten im Semester
Sommersemester 2019
Unterrichts-/ Lehrsprachen


This lecture series provides a detailed overview of the interactions of man-made organic and inorganic materials with biological systems. The emphasis is on the interaction of solid materials with biological systems. It does not require completion of the course “H802300 Biological Nanoscience and Nanotechnology”, but “Biomaterial interfaces and interactions” is meant to deepen the understanding of the material H802300 and to provide more detailed insights into its current practical implementation in the area of biomaterial and biointerface science and technology. Some overlap of entry level material will be given to allow new students to attend the course.

The students will start from the basic principles guiding interaction of biomolecules with each other and with foreign materials to build an understanding of the hierarchy of events that determines the fate of biomaterials (e.g. implants, biosensors and drug delivery vehicles) from the molecular to the tissue level. A major part of the course is therefore geared towards understanding the fundamentals of surfaces/interfaces, colloidal systems and polymer interactions. Design principles of biomaterial interfaces, which also give insights into interfaces of biological and biologially inspired materials, will be taught based on the fundamental understanding of interactions in biological systems.

A major part of the course provides an overview of a wide, but not complete, selection of the many techniques used to characterize (bio)material interfaces and interactions. The course puts emphasis on how the choice and limitation of techniques influence our current understanding of biomaterial performance and design. The characterization methods are studied from the physical principles underpinning their design. The goal is to learn what physical and chemical properties are actually measured by a technique and move away from a simplified view of characterization techniques as black boxes that deliver exact and universal quantities..

The course further in detail covers strategies to control the biological response of materials and surfaces using biological and synthetic surface modifications. The students will learn how to apply and evaluate such strategies to applications ranging from implants, to biosensors and anti-fouling (anti-microbial) surfaces, by studying examples of methods beyond what is currently state-of-the-art in industry.

Inhaltliche Voraussetzungen (erwartete Kenntnisse)

Basic knowledge in Physics, Chemistry, Biochemistry, and Mathematics.

Completion of the course “H802.300 Biological Nanoscience and Nanotchnology” is advantageous, but not required.


After the course the students will have a detailed understanding of the physical and chemical principles guiding biomolecular interactions with interfaces, and how biointerfaces form with foreign matter over many length scales (molecular to tissue). Importantly, they will have learned multiple ways of understanding the concept and properties of an interface in science and technology, and its defined relationship with the concept of interactions and free energy potentials on the nanoscale. They will understand the evaluation criteria for controlling the responses of materials with biological environments and to critically assess techniques used for their characterization. The students will acquire state-of-the-art knowledge of strategies to control the biological response of implants, anti-microbial interfaces and biosensors. In particular, the students will be introduced to the physical and chemical design of nanomaterials for biomedical and biotechnological applications ranging from biosensors to in vivo application of biomedical particles such as drug delivery vehicles.
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