Fusarium genome
F3705: Comparative annotation and analysis of multiple Fusarium genomes and the genomes of Brachypodium and crop plants with emphasis on toxin biosynthesis and detoxification reactions
The availability of genomes of multiple Fusarium strains and closely related species (F. graminearum, F. asiaticum, etc.) allows for comparative annotation and highlighting of strain specific genes and other genomic features. The project aims to further refine existing genome annotations and investigate the evolution of single genes and secondary metabolite clusters. Genome-wide analysis of host response and molecular events triggered by Fusarium infection thus far has suffered from the only fragmentary and unstructured genomic information available for the host genomes of barley and wheat. With the availability of structured genome drafts for these enormous Triticeae genomes important preconditions for the analysis and interpretation of responses in a genomic context are met. While further developing genomic data resources for these important crop plants as for the fungal pathogens, we aim to use exploit these for the analysis and interpretation of experimental data with a focus towards transcriptome analysis of host and pathogen upon infection. The work will be tightly linked with experimental partners F3702, F3703, F3708 and F3711.
Hans-Werner Mewes Prof.
Lehrstuhl f. Genomorientierte Bioinformatik
Wissenschaftszentrum Weihenstephan
Maximus-von-Imhof-Forum 3
85354 Freising Institut für Bioinformatik u. Systembiologie
Helmholtz Zentrum f. Gesundheit u. Umwelt
Ingolstädter Landstrasse 1
85764 Neuherberg
Supported by F.X. Mayer and U. Güldener