790120 Basics in bioprocessing

Semester hours
Lecturer (assistant)
Marx, Hans , Dürauer, Astrid
Offered in
Wintersemester 2022/23
Languages of instruction


This course discusses engineering principles involved in production of biomolecules (e.g., antibodies, enzymes, DNA) in living organisms (e.g., bacteria, yeast, tissue cultures). It include the bioprocess and the downstream processing -purification process. Examples will be taken from the following application areas: biopharmaceuticals, biomedical technologies, foods, and environmental processes.

The following topics will be addressed:
Basic elements of bioprocessing
Biological basics
Growth of microorganisms
Pure and mixed culture
Process control, analysis and monitoring
Cultivation of microorganisms in industrial scale
Design of bioreactors, special reactors and non-homogenous reactors
Scale up and sterile design

Downstream processing: properties of host systems and fermentation broths, biomass and product concentration, viscosity and density
Cell separation: centrifugation,filtration, flocculation
Cell disintegration
Adsorptive purification processes: chromatography
Process design

Previous knowledge expected

Objective (expected results of study and acquired competences)

Students will
Outcome 1: Learn and reinforce fundamental biology principles and how to apply them to engineering problems.

Outcome 2: Build mathematical models of cell growth, metabolism, bioreactor operation and downstream processes and apply them to solve engineering problems

Outcome 3: Understand the design of a biological production process.
You can find more details like the schedule or information about exams on the course-page in BOKUonline.