790356 Metabolic and cell engineering
- Type
- Lecture
- Semester hours
- 2
- Lecturer (assistant)
- Mattanovich, Diethard
- Organisation
- Offered in
- Sommersemester 2024
- Languages of instruction
- Englisch
- Content
-
Summary and update of cellular metabolism: catabolism and anabolism, energy conversion, reduction and oxidation equvalents.
Balances and equations describing cellular processes: mass, energy, redox and carbon balances; basic models to describe cells.
Application of metabolic modelling for metabolic and cell engineering.
Systems biology: describing the complexity of cellular systems.
Methods: metabolic flux analysis, metabolomics, transcriptomics, quantitative proteomics.
Tools for metabolic and cell engineering.
Major biotechnological challanges: New metabolic pathways leading to new products. Microbial stress during production. Protein secretion.
Applications of metabolic engineering: overproduction of metabolites with microorganisms.
Applications of cell engineering: improving cellular properties, e.g. secretion of recombinant proteins, strain robustness (stress resistance).
- Previous knowledge expected
-
Biochemistry and cellular physiology. Metabolic pathways and metabolic regulation. Metabolic modelling.
- Objective (expected results of study and acquired competences)
-
Students are familiar with principles of designing metabolic and cell engineering projects.
You can find more details like the schedule or information about exams on the course-page in BOKUonline.