790355 Introduction to metabolic modelling

Type
Lecture and exercise
Semester hours
2
Lecturer (assistant)
Zanghellini, Hans Jürgen
Organisation
Offered in
Sommersemester 2025
Languages of instruction
Englisch
Content

Computer models of biochemical networks are able to connect the genotype with the phenotype. In this primer we will give an introduction to biochemical network analysis. We will introduce basic concepts of network reconstruction and constraint based analysis of biological networks. In particular we will cover the process of building (genome scale) metabolic models and study the steady state behavior of these networks with flux balance analysis (FBA) and related methods. Finally we will show that these methods are successfully used in metabolic engineering, where FBA is a standard approach for the rationally designing microbial cell factories.

(*) Basic mathematical concepts in systems biology
(*) Reconstruction of biochemical networks
(*) Stoichiometric networks and their analysis
(*) Applications in biotechnology
.
Previous knowledge expected

Some knowledge of linear algebra is advantageous is very helpful but not a prerequisite
Objective (expected results of study and acquired competences)

After successful completion of this course, students
(*) Understand the challenges in mathematical modeling
(*) Know important types of mathematical models
(*) Are able to set up simple reaction network models
(*) Use metabolic models for exploration and strain design
(*) Know various data sources supporting metabolic analyses
You can find more details like the schedule or information about exams on the course-page in BOKUonline.