790367 Stem cells and tissue engineering

Type
Lecture
Semester hours
3
Lecturer (assistant)
Kasper, Cornelia , Holnthoner, Wolfgang , Wolbank, Susanne , Hafner, Christine
Organisation
Offered in
Wintersemester 2024/25
Languages of instruction
Englisch
Content

Within the lecture basic knowledge of regenerative medicine and cell based therapies will be mediated.

List of subjects:
Stem cells: definition, embryonic and adult stem cells (SC), growth, differentiation/development, niches
sources, manipulation/modification and characterization of SC
Embryonic stem cells: blastocyst, induced pluripotent stem cells, nuclear transfer (including epigenetic, reprogramming); adult: transdifferentiation, gene therapy
Structure, organization and control of cells and tissues
Immunological aspects, tolerance/rejection
Endogenous tissue regeneration/wound healing, strategies for reconstruction of specific tissues
Applications: SC in clinical applications e.g. hematopoietic SC therapy; Tissue Engineering of skin and bone
Biomaterials: classification, production, modification/functionalization; extra cellular matrix ECM and other biological matrices (inclusive decellularized materials)
Bioreactors/Engineering aspects in Tissue Engineering
Biomechanical stimulation of SC, fluid dynamics and mechanotransduction
ATMPs (Advanced Therapy Medicinal Products)
Biobanks e.g. Tissue Bank
Stem cell therapies in animals e.g. horse
Previous knowledge expected

Cell factories, Bioprocess Engineering, basic knowledge biochemistry
Objective (expected results of study and acquired competences)

After successful completion of this lecture, students are able to explain the different fields within regenerative medicine and cell based therapies. They understand different concepts within regeneative medicine e.g. cell therapy and tissue engineering and are able to discuss ethical and technological issues when using e.g. stem cells. They can identify and evaluate limitations and risks with modern cell based theapies e.g. gene therapy.
You can find more details like the schedule or information about exams on the course-page in BOKUonline.