NWNR001031 Fundamentals of Colloid and Interface Science

Type
Lecture
Semester hours
2
Lecturer (assistant)
Reimhult, Erik
Organisation
Colloid and Biointerface Science
Offered in
Wintersemester 2025/26
Languages of instruction
Englisch
Content

This lecture introduces colloid and interface science. We start with the definitions of colloidal systems and their fundamental thermodynamic properties. The students will study what determines the sometimes unexpected behavior of colloidal suspensions and what links colloid and interface science concerning forces and interactions.
We will focus on understanding colloidal systems of biological, medical, and biotechnological relevance, thereby treating how colloids in aqueous solvents are affected by high concentration, polymers, and high ionic strength, characteristic of biological systems. Additionally, the course provides the fundamentals for understanding polymers in the self-assembly of colloidal systems.
Half of the lecture series is devoted to the colloidal properties and design of biomedical nanoparticles, including imaging contrast agents and drug delivery vehicles, and to discussing nanomaterial risks from a colloidal science perspective. We will discuss the challenges of measuring well-defined properties for natural colloidal systems, which are also crucial for risk analysis.
Previous knowledge expected

Basic knowledge in physics, chemistry, molecular biology, and mathematics. Having passed the course “802300 Biological Nanosciences and Nanotechnology” or “802301 Biomaterial interfaces and interactions” is a suitable preparation.
Objective (expected results of study and acquired competences)

After successful completion of the course, students can:
1.Define and recall key concepts in colloid and interface science, including types of colloidal systems and dominant interparticle forces.
2.Describe how thermodynamic and kinetic principles influence colloidal stability, phase behavior, and particle interactions in solution.
3.Apply theoretical models such as the Stokes–Einstein equation, DLVO theory, and depletion interactions to analyze colloidal behavior.
4.Interpret and assess experimental data from techniques such as DLS, microscopy, and sedimentation to evaluate colloidal size and stability.
5.Compare and critically discuss stabilization mechanisms (electrostatic, steric, depletion) in lyophilic and lyophobic colloidal systems.
6.Evaluate nanoparticle-based systems for drug delivery, considering colloidal stability in biological fluids, triggered release, and toxicity risks.
7.Design a colloidal formulation for a targeted application by integrating knowledge of particle interactions, surface modifications, and environmental conditions.
You can find more details like the schedule or information about exams on the course-page in BOKUonline.