Radical Chemistry and Spin Traps

  • Synthesis of novel spin traps with prolonged lifetimes of their radical adducts
  • Synthesis of spin traps for use under extreme reaction conditions
  • Application of novel spin traps to investigate radical processes during cellulose degradation

Key publications:

  1. Rosenau, T.; Potthast, A.; Sixta, H.; Kosma, P. Tetrahedron 2002, 58 (15), 3073-3078. Radicals derived from N-methylmorpholine-N-oxide (NMMO): structure, trapping and recombination reactions.
  2. Stolze, K.; Udilova, N.; Rosenau, T.; Hofinger, A.; Nohl, H. Biochem. Pharmacol. 2004, 68, 185-193. Spin adducts of several N-2-(2-alkoxycarbonyl-propyl)--pyridylnitrone derivatives with superoxide, alkyl and lipid-derived radicals.
  3. Rosenau, T.; Potthast, A.; Möslinger, R.; Kosma, P. J. Wood Chem. Technol. 2006, 26(1), 1-11. Confirmation of the presence of hydroxyl radicals during pre-ripening of alkali cellulose.
  4. Stolze, K.; Rohr-Udilova, N.; Rosenau, T.; Stadtmüller, R.; Nohl, H. Biol Chem. 2005, 69, 1351-1361. Very stable superoxide radical adducts of 5-ethoxy-carbonyl-3,5-dimethylpyrroline-N-oxide (3,5-EDPO) and its derivatives.
  5. Stolze, K.; Rohr-Udilova, N.; Rosenau, T.; Hofinger, A.; Nohl, H. Bioorg. Med. Chem. 2007, 15, 2827-2836. Free radical trapping properties of several ethyl-substituted derivatives of 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO).