Neueste SCI Publikationen

Neueste Projekte

Forschungsprojekt aus §26 oder §27 Mitteln
Laufzeit : 2020-08-01 - 2023-10-31

Der Forschungsauftrag hat zum Ziel, die Grundwasserneubildung in den unterschiedlichen meteorologischen Gegebenheiten der Alpen zu identifizieren und klimabedingte Änderungen dieser zu untersuchen. Andererseits gilt es, die Wasserreserven, die als Permafrosteis in intakten Blockgletschern gespeichert sind, zu quantifizieren. Damit soll der Wissenstand über die Auswirkungen des Klimawandels auf den alpinen Permafrost wesentlich erweitert werden, damit sich die öffentliche Hand frühzeitig auf die damit zusammenhängenden Herausforderungen vorbereiten kann.
Forschungsprojekt aus §26 oder §27 Mitteln
Laufzeit : 2021-06-01 - 2025-10-31

Strain and process improvement is one of the most labor-intensive and time-consuming phases of biotechnology process development. High-throughput screening is usually in miniaturized static cultures which compromises scalability, so that further intermediate screening steps are needed. Maturing of existing technology to deal with additional cell culture types (i.e. mammalian cells) and incorporate further analytical developments to support metabolite and product screening requirements are identified as the key steps to creating a technology of commercial value. In this project, we propose to mature an existing µ-screening platform with two major pillars addressing these steps. Firstly, extending the applicability of the module to fermentation technology based on Chinese Hamster Ovary (CHO) cultures. Secondly, to expand the analytical value of the platform using a combination of valve technology and mass spectrometry to develop a fully integrated platform suitable for application in biotechnology facilities.
Forschungsprojekt aus §26 oder §27 Mitteln
Laufzeit : 2020-11-01 - 2023-02-28

The combination of ion mobility-mass spectrometry (IM-MS) with separation techniques such as liquid chromatography (LC) is now emerging as a powerful platform for addressing the identity confirmation of unknown organic compounds within complex samples. Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are two widespread ion sources for IM-MS, in which the mechanism of ionization is based on protonation/deprotonation of the analyte or cation/anion attachment. Studying these phenomena theoretically alongside experimental confirmation on a commercially available instrument is recognized as a key aspect of addressing the broad analysis of unknown compounds via untargeted workflows, where several 1000 molecular features are typically resolved within a single LC-IM-MS analysis. In an IM-MS platform equipped with APCI or ESI ion sources, the formation of the product ions and consequently the sensitivity of IM-MS to a given analyte, M, depends on the nature of M, the source conditions applied, and solvents during ionization processes. As such, establishing an improved knowledge about the ion/molecule reactions occurring in the ionization region of an IM-MS, potential conformations of ionic species, the nature of the ion/molecule interactions, and the parameters influencing these interactions enables analytical chemists to modify the existing analytical techniques to improve their detection limits and sensitivities, provide better characterization of unknown molecules, and/or to avoid some interferences that reduce the analytical performance.

Betreute Hochschulschriften