Michael Baumschabl received the OeGMBT PhD Award 2024
Congratulations to Michael Baumschabl, who has been awarded the prestigious PhD Award at this year’s ÖGMBT conference for his outstanding dissertation. His research significantly improved the synthetic autotrophic strain Komagataella phaffii, which uses CO2 as its sole carbon source, enabling it to produce up to 600 mg/L of lactic acid. Additionally, he discovered a natural recycling pathway for the toxic byproduct 2-phosphoglycolate through the deletion of the CYB2 gene.
The potential of CO2-based production cycles in biotechnology to fight the climate crisis
Bachleitner, S; Ata, Ö; Mattanovich, D. (2023)
Nat Commun. 2023 Nov 1;14(1):6978. doi: 10.1038/s41467-023-42790-6.
Fermenting the future – on the benefits of a bioart collaboration
In this article Diethard Mattanovich, Martin Altvater, Özge Ata and Simone Bachleitner explore the intersection of science and art through a collaboration between us scientists and the bioartists Anna Dimitriu and Alex May, focusing on the interface of yeast biotechnology and art.
FEMS Yeast Research, Volume 24, 2024, foae004, https://doi.org/10.1093/femsyr/foae004
Fermenting Futures project is exhibited in “Fungi: In Art and Science” at the at the Nobel Prize Museum Stockholm
from 30th September 2023 – 7th January 2024 the project "Fermenting Futures" of Anna Dumitriu and Alex May, created in cooperation with acib and our research group, will be part of the autumn exhibition
"Fungi – In Art and Science", the world of fungi is explored through artworks, design objects, fashion and current scientific research.
European Researcher's Night 2023
On September 29, 2023, our group participated in the European Researcher's Night 2023 in Vienna. It was an impressive event for all participants again this year!
Christian Doppler Laboratory for Growth-Decoupled Protein Production in Yeast
A report on the CD-lab of Brigitte Gasser in the magazine "Chemiereport 2017-03" (text only available in German).
A native phosphoglycolate salvage pathway of the synthetic autotrophic yeast Komagataella phaffii
Baumschabl, M; Mitic BM; Troyer, C; Hann, S; Ata, Ö; Mattanovich D. (2024). Microlife. 2023 Dec 11:5:uqad046. doi: 10.1093/femsml/uqad046. eCollection 2024.
Carbon efficient production of chemicals with yeasts
Vásquez Castro, E; Memari, G; Ata, Ö; Mattanovich, D. (2023)
Yeast. 2023 Dec;40(12):583-593. doi: 10.1002/yea.3909. Epub 2023 Nov 23.
Customizing amino acid metabolism of Pichia pastoris for recombinant protein production.
Rußmayer H, Buchetics M, Mattanovich M, Neubauer S, Steiger M, Graf AB, Koellensperger G, Hann S, Sauer M, Gasser B, Mattanovich D. Biotechnol J. 2023 Sep 5:e2300033. doi: 10.1002/biot.202300033. Online ahead of print. PMID: 37668396
Pushing and pulling proteins into the yeast secretory pathway enhances recombinant protein secretion
Richard J. Zahrl, Roland Prielhofer, Özge Ata, Kristin Baumann, Diethard Mattanovich and Brigitte Gasser published their results on how to improve the bottleneck of secretion of recombinants proteins in Komagataella spp.
Metab Eng. 2022 Nov;74:36-48. doi: 10.1016/j.ymben.2022.08.010. Epub 2022 Sep 1.
Turnaround for the chemical industry: VIVALDI transforms CO2 emissions into sustainable bioproducts
The European Union has granted €7 million for the VIVALDI project to transform the bio-based industry into a new, more environmentally friendly and competitive sector. BOKU received the second largest share of the project volume in this context.
The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO2 in the yeast Komagataella phaffii
Mitic, BM; Troyer, C; Lutz, L; Baumschabl, M; Hann, S; Mattanovich, D. (2023) Nat Commun. 2023 Nov 27;14(1):7754. doi: 10.1038/s41467-023-43610-7.
Tailored extraction and ion mobility-mass spectrometry enables isotopologue analysis of tetrahydrofolate vitamers.
Mitic BM, Mattanovich D, Hann S, Causon T. Anal Bioanal Chem. 2023 Sep;415(21):5151-5163. doi: 10.1007/s00216-023-04786-5. Epub 2023 Jun 22. PMID: 37347300
Synthetic activation of yeast stress response improves secretion of recombinant proteins.
Zahrl RJ, Prielhofer R, Burgard J, Mattanovich D, Gasser B. N Biotechnol. 2023 Mar 25;73:19-28. doi: 10.1016/j.nbt.2023.01.001. Epub 2023 Jan 2. PMID: 36603701
From strain engineering to process development: monoclonal antibody production with an unnatural amino acid in Pichia pastoris
Nora Tir, Lina Heistinger, Clemens Grünwald-Gruber, Leo A Jakob, Stephan Dickgiesser , Nicolas Rasche and Diethard Mattanovich published their results on how Pichia pastoris was successfully employed for cost-effective laboratory-scale production of a monoclonal antibody with an unnatural amino acid. Microb Cell Fact. 2022 Aug 11;21(1):157. doi:10.1186/s12934-022-01882-6.
Recombinant Protein Production in Yeast
This volume provides an overview of the main yeast production platforms currently used and future yeast cell factories for recombinant protein production. Chapters detail approaches of genetic and metabolic engineering, co-factor containing proteins and virus-like particles, glycoproteins, and post-translational modifications of proteins.
in: Methods Mol Biol. 2019;1923: ISBN-13: 978-1493990238