773114 Practical course in organic chemistry


Type
Exercise course
Semester hours
3
Lecturer (assistant)
Organisation
Offered in
Sommersemester 2021
Languages of instruction
Englisch

Content

Synthesis and purification of organic substances (extraction, distillation, recrystallization, chromatography)
Criteria of purification (melting point, boiling point, refractive index)
Spectroscopic analysis NMR, IR)
Literature search, safety regulations


Colloquium – table of contents

Basics in organic chemistry (see lecture course organic chemistry for food science and biotechnology), substance categories, reactions and mechanisms in organic chemistry, nomenclature

Purification of substances (preparation in pure form)
• Crystallization
• Sublimation
• Distillation (in vacuum/normal pressure, rectification, azeotropic distillation)
• Standard equipment in organic chemistry
• Separation techniques in organic chemistry (including separation by extraction, based on compound acidity)
• Chromatography (theory, overview) with focus on thin layer and column chromatography.

Purity control
• Determination of melting and boiling point
• Refractive index
• Optical rotation
• Solvent drying

Lab safety
• Safe handling of chemicals (labelling, GHS/CLP, H/P statements, LD50, maximum workplace concentration value)
• Solvents; toxicity, inflammability, labelling, disposal
• Laboratory gas (Nitrogen, Helium, Argon,…) labelling, control armatures

Structure elucidation of organic compounds
• Basics in nuclear magnetic resonance and infrared spectroscopy

Miscellaneous
• Security measures for handling carcinogens and mutagenic substances
• Flammable liquids (handling, precautions, examples)
• Operations in an organic chemistry lab
• Working methods (Installation of experimental apparatus, filtration, recrystallization, distillation, chromatography)
• Use of enzymes in organic chemistry – reductases

Previous knowledge expected

basics in organic chemistry

Objective (expected results of study and acquired competences)

Learning the basic working methods of organic chemistry as well as the preparation and isolation of natural substances.
Practical experience in the extraction of organic compounds based on different solubilities in organic and aqueous solutions
Application of Nernst's distribution theorem, acid / base properties and polarity for the separation of substances
Construction and handling of simple synthesis equipment. Assessment of the purity on the basis of the material constants determined
Basic interpretation of nmr and ir spectra
Learning about safe handling and proper disposal of organic waste
Experience in using chemical databases
You can find more details like the schedule or information about exams on the course-page in BOKUonline.