773310 Bioorganic chemistry

Type
Lecture
Semester hours
2
Lecturer (assistant)
Organisation
Offered in
Sommersemester 2023
Languages of instruction
Englisch
Content

Structural Biology of Biomolecules
Introduction into X-ray crystallography and NMR spectroscopy of biomolecules

Chemistry of Nucleic Acids
Chemistry of N-heterocycles and phosphoesters
Structure and chemistry of DNA and RNA
Ribonucleases, ribozymes, DNA-polymerases
Oligonucleotide syntheses, nucleotide analogs

Lipids
Orbital-symmetry controlled reactions
Biosynthesis of sterols, chemistry of vitamin D

Carbohydrates
Bacterial polysaccharides, biosynthesis of peptidoglycan, lysozyme Biosynthesis and immunobiology of lipopolysaccharides
Catalytic mechanisms of glycosidases and glycosyl transferases
Chemistry and biology of neuraminic acid, neuraminidases

Proteins
Chemistry of amino acids, solid phase syntheses, combinatorial chemistry
Synthesis of peptides and glycopeptides, proteinases
Previous knowledge expected

Fundamental knowledge of biochemistry and organic chemistry
Objective (expected results of study and acquired competences)

After completing this course and passing the exam the students should understand the general factors involved in enzymatic reaction mechanisms. In particular, the similarity between organic reactions, functional groups and the reactive groups in the active centre of enzymes will be appreciated as well as the mechanistic similarity between degrading and polymerizing enzymes. The students will also be familiar with the three-dimensional aspects of enzymatic reactions using examples from the protein database and nmr spectroscopy
You can find more details like the schedule or information about exams on the course-page in BOKUonline.