772114 Biochemistry of metabolism

Type
Lecture
Semester hours
3
Lecturer (assistant)
Traxlmayr, Michael , Obinger, Christian
Organisation
Offered in
Sommersemester 2023
Languages of instruction
Deutsch
Content

Basic features and mechanisms of human catabolic and anabolic metabolism including regulation and coordination. Presentation of representatives of the 6 enzyme classes and role of vitamins as precursors of cofactors in enzymes.
The following topics are covered in detail: Biochemical reaction mechanisms as well as thermodynamics of biological systems, glycolysis, substrate chain phosphorylation, fates of pyruvate (comparison of homolactic fermentation, alcoholic fermentation and oxidative utilization), citrate cycle (reference to glyoxylate cycle), respiratory electron transport, oxidative phosphorylation, glycogen metabolism, gluconeogenesis, oxidative pentose phosphate pathway, regulation and coordination of carbohydrate metabolism (allosteric enzymes, substrate cycles, hormones, signal transduction), protein and amino acid degradation (urea cycle), and lipid metabolism.
Presentation of exemplary vitamins in metabolism (B1, B2, B3, B4, B6, C and A).
Mechanisms of representative enzymes of the six enzyme classes in the context of the metabolic pathways discussed.
Previous knowledge expected

"Organic chemistry" and "Basics in biochemistry": Knowledge of chemistry and structure of biomolecules (proteins, carbohydrates, lipids, purins and pyrimidines)
.
Objective (expected results of study and acquired competences)

After successful completion of the course, the student should know the basic features of biological energy conservation and (bio)chemical reaction principles of degradative and anabolic human metabolism. Students should recognize the relationship between thermodynamics and regulation and the role of primary (hormones) and secondary messengers in the coordination of metabolic pathways. Another important goal is to demonstrate the relationship between vitamins and enzymatic cofactors and basic reactive mechanisms of representatives of the six classes of enzymes.
You can find more details like the schedule or information about exams on the course-page in BOKUonline.