A major focus in the group is ion mobility-mass spectrometry (IM-MS). In addition to providing a highly precise and rapid separation dimension, new structural information can be derived for gas phase ions including the collision cross section (CCS). We use both drift tube (DTIM) and high-resolution Structures for Lossless Ion Manipulation (SLIM) technologies. From 2024-2028, we are coordinating the MSCA Doctoral Network MobiliTraIN (Ion Mobility Mass Spectrometry Training Network) with 13 Doctoral Candidates working together across Europe with leading academic researchers, IM-MS instrument developers and industry partners.

LC-MS/MS and LC-HRMS are used for analytical metabolomics in the context of biotechnology and bioprocess engineering (e.g., metabolic engineering, modelling and pathway analysis) in collaboration with the experienced teams within the Hann Group and at the Institute of Microbiology and Microbial Biotechnology. Most recently, new microfluidic perfusion fermentation technology is being integrated into an online analytical platform in collaboration with the Hann and Mattanovich groups.

In collaboration with VinoStellar OG, the SmartVinify project involves the development and implementation of analytical tools for the prediction of grape and wine quality as well as authenticity assessment.

Analytical method development is also performed in the group using IM-MS, LC-MS, ion (exchange) chromatography (IC), and capillary electrophoresis (CE) for diverse applications, often performed at the Core Facility Mass Spectrometry.

A list of publications is available here.

Recent research highlights

New publications

Using SLIM for steroid analysis (Application Note, Sabrina Cramer)

Complete workflow for CCS quality control for IM-MS lipidomics (Felina Hildebrand, Koellensperger Lab)

Find all the CCS data in DTIM-MS datasets (Sangeeta Kumari)

In-source ion activation and IM-MS to study intramolecular proton transfer (Younes Valadbeigi)

Isotopologue distribution analysis for tetrahydrofolate vitamers (Bernd Mitic)

Why your external calibration practices matter for small molecule CCS determination (Max Feuerstein)

How (un)certain are you about CCS determination?

 

Recently Completed Research Projects

Dr. Younes Valadbeigi (FWF Lise Meitner Fellow, 2021-2023) “Ion Formation in Ion Mobility-Mass Spectrometry

Collaborations/partners

The group is cooperating with academic and industrial partners


BOKU partners:

Astrid Dürauer
Institute of Bioprocess Science and Engineering
(Collaborations within BOKU Doctoral School Bioprocess Engineering and Christian Doppler Laboratory “Knowledge-Based Production of Gene Therapy Vectors”)

Brigitte Gasser
Institute of Microbiology and Microbial Biotechnology
(Collaborations within MSCA Doctoral Network “MobiliTraIN”)

Diethard Mattanovich
Institute of Microbiology and Microbial Biotechnology
(Collaborations within acib and BOKU Doctoral School Bioprocess Engineering)


Academia & Industry:

acib
Austrian Centre of Industrial Biotechnology (COMET)

Agilent Technologies 

Stephen Blanksby
Queensland University of Technology

Gunda Köllensperger
University of Vienna

MOBILion Systems Inc.

MobiliTraIN Network
(full list of 21 partners available using link)