Poly-urethane vascular graft
Mechanical behavior and macrophage-mediated degradation
Macrophages are critical players in host response, remodeling and degradation. However, an assessment tool to evaluate the degradation of biodegradable materials in a more physiological environment is still needed. Dr Marjan Enayati (Medical University Vienna) has developed an in vitro model based on monocyte-derived macrophage cell culture that allows long-term analysis of degradation and mechanical properties of polyurethanes (TPU). Professor José Luis Toca-Herrera and Dr Jagoba Iturri from Institute for Biophysics (Department of Nanobiotechnology) contributed to the detection of surface defects in the fibrous structure of these scaffolds as degradation proceeds, mediated by activated macrophages both in vitro and in vivo, by employing Atomic Force Microscopy and Scanning Electron Microscopy techniques.