Department für Nanobiotechnologie (DNBT)

  • BIMat

    H802

  • Biophysik

    H803

  • Synthetische Bioarchitekturen

    H804

Research article published in Nature, Scientific Reports

Reduction of beta‑2‑glycoprotein I induces protein flexibility and alters pathogenic antibody binding
Researchers from the Institute for Biophysics (Department of Nanobiotechnology) in collaboration with the group of Prof. Mihaela Delcea (University of Greifswald) and Prof. Anisur Rahman (University College London), have studied the effect of β2GPI reduction on the protein structure, and its implications for antibody binding in autoimmune disorder antiphospholipid syndrome patients.

Call for Master Theses

Applications open now!
The candidates should be focused on the field of biotechnology, microbiology, biochemistry or related studies. We appreciate highly motivated students who are excellent team players with the ability to work independently under supervision in an interdisciplinary and very friendly research environment.

PhD Position open

The bacterial glycome - A sign post for oral health versus disease?
Oral biofilm (“dental plaque”) is a rich reservoir of microorganisms, including Tannerella species. The recently identified, oral health-associated, Tannerella serpentiformis is the closest relative of T. forsythia. We have evidence that the glycomes of these two Tannerella species differ in key aspects and we hypothesize that this translates into differences of the oral health status.

Scientific article: Synthesis of short-range ordered aluminosilicate

Can you synthesize silicates that mimic volcanic soils?
Our colleagues at the University of Hohenheim synthesized and processed short-range ordered aluminosilicates, important to understand, e.g., volcanic soil properties. These materials required advanced characterization to determine their properties and similarities with naturally occurring material. BIMat contributed transmission electron microscopy characterization of these samples so that their morphology could be understood and related to their surface-based reactivity for a publication in Scientific Reports.

Scientific article: Mopping heavy metals with nanoparticles

Polymer shells bind heavy metals that magnetic particles can remove
Three research groups combined their expertise to develop magnetic core-shell nanoparticles that would be colloidally stable, efficiently bind heavy metal ions and have a core that could allow magnetic extraction to remove the captured toxic ions. With a theoretical model describing the particles, this proof-of-concept published in ACS Applied Materials & Interfaces can now be further explored and optimized for applications.

Scientific paper

Atomic Force Microscopy on Astrocyte purinergic receptor P2Y recognition
Researchers from the Institute for Biophysics (Department of Nanobiotechnology) in collaboration with the group of Prof. Maria Teresa Miras-Portugal (Univ. Complutense Madrid, Spain), have employed Atomic Force Microscopy to detect and evaluate the impact of selective stimulation on native nucleotide receptors on the mechanical response of both endothelial cells and astrocytes.

Scientific article: Running circles around proteins

Cyclic polymer grafts make stealth nanoparticles
Nanoparticles for biomedical and biotechnological applications must remain undetected by the body, which means avoiding binding of proteins from biological fluids such as blood. This challenge remains unsolved for inorganic nanoparticles, such as those used for biomedical imaging. In a study published in ACS Nano, we show that coating particles with cyclic polymers prevents binding of the stickiest and most abundant blood protein, human serum albumin.

Scientific article: Some blood proteins always stick

Polymer brush nanoparticles get involuntarily tagged
The fate of nanoparticles in a biological system is determined by their protein corona, as remodeling of their surface properties through protein adsorption triggers specific recognition such as cell uptake and immune system clearance and nonspecific processes such as aggregation and precipitation. Using the most sensitive measurements so far, we demonstrate that state-of-the-art biomedical nanoparticles get tagged by sticky marker proteins in the blood.

Actin disruption influences cell response upon deformation at different scales

Dr Jagoba Iturri and Professor José Luis Toca-Herrera from the Institute for Biophysics (Department of Nanobiotechnology) have studied, in collaboration with researchers from the University of Ljubljana (Slovenia), the mechanical response of endothelial cells upon treatment with cytoskeleton-disrupting drugs (CK-869 and Jasplakinolide). Mechanical properties were measured by deformation at two different ranges by means of complementary Optical Tweezers and Atomic Force Microscopy techniques.

Leitung und Sekretariat

Departmentleiter

Univ.Prof. Dr.
 José Luis Toca-Herrera
Stellvertreterin

Univ.Prof. Dr.rer.nat.
 Eva-Kathrin Ehmoser
Stellvertreter

Univ.Prof. Dr.
 Erik Reimhult
Sekretariat

Dr.
 Tiziana Fresu
Sekretariat

Amtsdir.
 Dieter Jäger

Adressen & Kontakt

H80000 Department für Nanobiotechnologie (DNBT)

Simon Zeisel Haus
Muthgasse 11/II
1190 Wien

×

weitere anzeigen

H80200 Institut für Biologisch inspirierte Materialien

Simon Zeisel Haus
Muthgasse 11/II
1190 Wien

×
H80300 Institut für Biophysik

Simon Zeisel Haus
Muthgasse 11/II
1190 Wien

×
H80400 Institut für Synthetische Bioarchitekturen

Simon Zeisel Haus
Muthgasse 11/II
1190 Wien

×