Major achievements
The interdisciplinary team investigated the dynamics of the transcriptomes and metabolomes during the plant-pathogen interaction. Major achievements were the establishment of several GC-MS and LC-MS metabolomics workflows and the implementation of stable isotopic labelling. Several novel plant metabolites of the major mycotoxin and virulence factor deoxynivalenol (DON) were discovered. Genes encoding relevant plant detoxification enzymes such as UDP-glucosyltransferases and glutathione-S-transferases were identified despite the difficulties caused by the enormous size of these gene families in hexaploid wheat. The collaboration with the bioinformatics partner from Helmholtz Zentrum München / TU München was very important to achieve this goal. The gene inventory of F. graminearum revealed many secondary metabolite clusters with mostly unknown products. The role of Fusarium chromatin modification was investigated, revealing a strong impact of active plant defense on formation of secondary metabolites and virulence. It could be shown that NPS1 is required for production of the siderophore malonichrome, and that the metabolites culmorin and butenolide are inhibitors of DON detoxification enzymes. The molecular basis for the formation of novel trichothecenes by F. graminearum strains (NX-toxins) was elucidated. The toxicity of new compounds and combinations of metabolites in mammalian cells was studied by the toxicology partner from the University of Vienna. Regarding plant interaction, we discovered that Fusarium is able to hydrolyse tryptamine derived plant defense compounds (e.g. coumaroyl-tryptamine) and to convert tryptamine into auxin. A strain with knockouts in seven amine-oxidase genes revealed that auxin formation is indeed a virulence factor. Two major resistance QTL utilized by plant breeders were studied by transcriptomics and metabolomics approaches. A contig spanning the Fhb1 resistance QTL was established and four loss of DON resistance and Fusarium resistance mutant lines are currently sequenced and compared to the wild-type to pinpoint the causal Fhb1 gene. For the difficult centromeric region conferring resistance to initial infection, fine mapping using gamma-radiation derived deletion lines led to a list of candidate genes. The insights gained by the SFB project will contribute to a sustainable solution of the Fusarium problem by knowledge-based resistance breeding.
Publications A - Z (2009 - 2018)
Adam, G. Wiesenberger, G; Gueldener, U (2015): Fusarium Mycotoxins and their Role in Plant-Pathogen Interaction. In: Zeilinger, S., J-F, M., Garcia-Estrada, C. (Eds.) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 Springer, New York, Heidelberg, Dordrecht, London.; DOI: 10.1007/978-1-4939-2531-5; link.springer.com/chapter/10.1007/978-1-4939-2531-5_10
Berthiller, F; Dall'asta, C; Corradini, R; Marchelli, R; Sulyok, M; Krska, R; Adam, G; Schuhmacher, R (2009): Occurrence of deoxynivalenol and its 3-D-glucoside in wheat and maize. Food Addit Contam Part A-CH 26(4): 507-511.; DOI: 10.1080/02652030802555668; dx.doi.org/10.1080/02652030802555668
Berthiller, F; Hametner, C; Krenn, P; Schweiger, W; Ludwig, R; Adam, G; Krska, R; Schuhmacher, R (2009): Preparation and characterization of the masked Fusarium mycotoxins zearalenone-4O-beta-D-glucopyranoside, alpha-zearalenol-4O-beta-D-glucopyranoside and beta-zearalenol-4O-beta-D-glucopyranoside by MS/MS and 2D-NMR. Food Addit Contam, 26, 207-213.; DOI: 10.1080/02652030802399034; dx.doi.org/10.1007/s00216-009-2874-x
Berthiller, F; Krska, R; Domig, KJ; Kneifel, W; Juge, N; Schuhmacher, R; Adam, G (2011): Hydrolytic fate of deoxynivalenol-3-glucoside during digestion. Toxicol Lett. 2011; 206(3):264-267.; DOI : 10.1016/j.toxlet.2011.08.006; dx.doi.org/10.1016/j.toxlet.2011.08.006 (OA)
Berthiller, F; Schuhmacher, R; Adam, G; Krska, R (2009): Formation, determination and significance of masked and other conjugated mycotoxins. Anal Bioanal Chem 395(5):1243-1252. DOI: dx.doi.org/10.1007/s00216-009-2874-x
Boedi, S., Berger, H., Sieber, C., Munsterkotter, M., Maloku, I., Warth, B., Sulyok, M., Lemmens, M., Schuhmacher, R., Guldener, U., Strauss, J., 2016. Comparison of Fusarium graminearum Transcriptomes on Living or Dead Wheat Differentiates Substrate-Responsive and Defense-Responsive Genes. Front Microbiol 7, 1113. DOI: 10.3389/fmicb.2016.01113. www.ncbi.nlm.nih.gov/pubmed/27507961
Boedi, S., Reyes-Dominguez, Y., Strauss, J., 2012. Chromatin immunoprecipitation analysis in filamentous fungi. Methods Mol Biol 944, 221-236. DOI: 10.1007/978-1-62703-122-6_16. www.ncbi.nlm.nih.gov/pubmed/23065620
Bringmann M, Landrein B, Schudoma C, Hamant O, Hauser MT, Persson S. Cracking the elusive alignment hypothesis: the microtubule-cellulose synthase nexus unraveled. Trends Plant Sci. 2012 Nov;17(11):666-74. doi: 10.1016/j.tplants.2012.06.003.
Bringmann M, Li E, Sampathkumar A, Kocabek T, Hauser MT, Persson S. POM-POM2/cellulose synthase interacting1 is essential for the functional association of cellulose synthase and microtubules in Arabidopsis. Plant Cell. 2012 Jan;24(1):163-77. doi: 10.1105/tpc.111.093575.
Broekaert, N; Devreese, M; Demeyere, K; Berthiller, F; Michlmayr, H; Varga, E; Adam, G; Meyer, E; Croubels, S (2016): Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells. Food and Chemical Toxicology 95: 103-109. DOI: dx.doi.org/10.1016/j.fct.2016.06.012 (OA)
Broekaert, N; Devreese, M; van Bergen, T; Schauvliege, S; De Boevre, M; De Saeger, S; Vanhaecke, L; Berthiller, F; Michlmayr, H; Malachová, A; Adam, G; Vermeulen, A; Croubels, S (2017): In vivo contribution of deoxynivalenol-3-β-D-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics. Arch Toxicol. 91(2):699-712; DOI: 10.1007/s00204-016-1710-2 ; link.springer.com/article/10.1007%2Fs00204-016-1710-2 (OA)
Buerstmayr, H; Adam, G; Lemmens, M (2012): Resistance to head blight caused by Fusarium spp. in wheat. In: Sharma I (ed) Disease resistance in wheat, 1. edn. CAB International, Wallingford, UK, pp 236-276.; DOI: 10.1079/9781845938185.0236; ISBN: 9781845938185https://www.cabi.org/cabebooks/ebook/20123159066
Buerstmayr, H; Buerstmayr, M; Schweiger, W; Steiner, B (2013): Genomics-Assisted Breeding for Fusarium Head Blight Resistance in Wheat. In: Translational Genomics for Crop Breeding (Vol. I, pp. 45–61). John Wiley & Sons Ltd. ; DOI: 10.1002/9781118728475.ch4; onlinelibrary.wiley.com/doi/pdf/10.1002/9781118728475.ch4 (No OA)
Buerstmayr, H; Buerstmayr, M; Schweiger, W; Steiner, B (2014): Breeding for resistance to head blight caused by Fusarium spp. in wheat. In: CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources. 1-13.
Buerstmayr, M; Buerstmayr, H (2015): Comparative mapping of quantitative trait loci for Fusarium head blight resistance and anther retention in the winter wheat population Capo × Arina. Theor Appl Genet 128(8): 1519–1530.; DOI: 10.1007/s00122-015-2527-8; dx.doi.org/10.1007/s00122-015-2527-8 (Hybrid OA)
Buerstmayr, M; Huber, K; Heckmann, J; Steiner, B; Nelson, JC; Buerstmayr, H (2012): Mapping of QTL for Fusarium head blight resistance and morphological and developmental traits in three backcross populations derived from Triticum dicoccum x T. durum. Theor Appl Genet 125:1751–1765.; DOI: 10.1007/s00122-012-1951-2; link.springer.com/article/10.1007%2Fs00122-012-1951-2 (Hybrid OA)
Buerstmayr, M; Steiner, B; Wagner, C; Schwarz, P; Brugger, K; Barabaschi, D; Volante, A; Valè, G; Cattivelli, L; Buerstmayr, H (2018): High-resolution mapping of the pericentromeric region on wheat chromosome arm 5AS harbouring the Fusarium head blight resistance QTL Qfhs.ifa‐5A. Plant Biotechnology Journal 16(5):1046-1056.; DOI:10.1111/pbi.12850; dx.doi.org/10.1111/pbi.12850 (OA)
Bueschl, C., Kluger, B., Lemmens, M., Adam, G., Wiesenberger, G., Maschietto, V., Marocco, A., Strauss, J., Bodi, S., Thallinger, G.G., Krska, R., Schuhmacher, R., 2014. A novel stable isotope labelling assisted workflow for improved untargeted LC-HRMS based metabolomics research. Metabolomics 10, 754-769. DOI: 10.1007/s11306-013-0611-0. www.ncbi.nlm.nih.gov/pubmed/25057268
Bueschl, C; Kluger, B; Berthiller, F; Lirk, G; Winkler, S; Krska, R; Schuhmacher, R (2012): MetExtract: a new software tool for the automated comprehensive extraction of metabolite-derived LC/MS signals in metabolomics research. Bioinformatics. 2012; 28(5):736-738. DOI: dx.doi.org/10.1093/bioinformatics/bts012
Bueschl, C; Kluger, B; Lemmens, M; Adam, G; Wiesenberger, G; Maschietto, V; Marocco, A; Strauss, J; Bodi, S; Thallinger, GG; Krska, R; Schuhmacher, R (2014): A novel stable isotope labelling assisted workflow for improved untargeted LC-HRMS based metabolomics research. METABOLOMICS 10(4): 754-769.; DOI: 10.1007/s11306-013-0611-0; link.springer.com/article/10.1007%2Fs11306-013-0611-0 (OA)
Bueschl, C; Kluger, B; Neumann, NKN; Doppler, M; Maschietto, V; Thallinger, GG; Meng-Reiterer, J; Krska, R; Schuhmacher, R (2017) MetExtract II: A Software Suite for Stable Isotope-Assisted Untargeted Metabolomics. Anal Chem 89(17): 9518-9526. DOI: dx.doi.org/10.1021/acs.analchem.7b02518
Bueschl, C; Krska, R; Kluger, B; Schuhmacher, R (2013): Isotopic labeling-assisted metabolomics using LC-MS. Anal Bioanal Chem 405(1): 27-33. DOI: dx.doi.org/10.1007/s00216-012-6375-y
Canovas, D., Marcos, A.T., Gacek, A., Ramos, M.S., Gutierrez, G., Reyes-Dominguez, Y., Strauss, J., 2014. The histone acetyltransferase GcnE (GCN5) plays a central role in the regulation of Aspergillus asexual development. Genetics 197, 1175-1189. DOI: 10.1534/genetics.114.165688. www.ncbi.nlm.nih.gov/pubmed/24907261
Canovas, D., Studt, L., Marcos, A.T., Strauss, J., 2017. High-throughput format for the phenotyping of fungi on solid substrates. Sci Rep 7, 4289. DOI: 10.1038/s41598-017-03598-9. www.ncbi.nlm.nih.gov/pubmed/28655890
Cirlini, M; Barilli, A; Galaverna, G; Michlmayr, H; Adam, G; Berthiller, F; Dall’Asta, C (2016): Study on the uptake and deglycosylation of the masked forms of zearalenone in human intestinal Caco-2 cells. Food Chem Toxicol. 98(Pt B):232-239.; DOI: 10.1016/j.fct.2016.11.003 ; www.sciencedirect.com/science/article/pii/S0278691516304033 (OA)
Del Favero, G; Woelflingseder, L; Braun, D; Puntscher, H; Küt,t ML; Dellafiora, L; Warth, B; Pahlke, G; Dall’Asta, C; Adam, G; Marko, D (2018): Similarities and differences in the response of intestinal HT-29 cells to trichothecene mycotoxin deoxynivalenol and its sulfated conjugates. Toxicology Letters (revised manuscript submitted)
Derntl, C; Kluger, B; Bueschl, C; Schuhmacher, R; Mach, RL; Mach-Aigner, AR (2017): Transcription factor Xpp1 is a switch between primary and secondary fungal metabolism. P Natl Acad SciCI USA, 114(4): E560-E569. DOI: dx.doi.org/10.1073/pnas.1609348114
Doppler, M; Kluger, B; Bueschl, C; Schneider, C; Krska, R; Delcambre, S; Hiller, K; Lemmens, M; Schuhmacher, R (2016): Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants. Int J Mol Sci 17(7). DOI: dx.doi.org/10.3390/ijms17071017
Faus I, Niñoles R, Kesari V, Llabata P, Tam E, Nebauer SG, Santiago J, Hauser MT, Gadea J. Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation. J Plant Physiol. 2018 May - Jun;224-225:173-182. doi: 10.1016/j.jplph.2018.04.003.
Fruhmann, P; Hametner, C; Mikula, H; Adam, G; Krska, R; Frohlich, J (2014): Stereoselective Luche Reduction of Deoxynivalenol and Three of Its Acetylated Derivatives at C8. Toxins 6(1): 325-336.; DOI: 10.3390/toxins6010325; www.mdpi.com/2072-6651/6/1/325 (OA)
Fruhmann, P; Mikula, H; Wiesenberger, G; Varga, E; Lumpi, D; Stöger, B; Häubl, G; Lemmens, M; Berthiller, F; Krska, R; Adam, G; Hametner, C; Fröhlich, J (2014): Isolation and structure elucidation of pentahydroxyscirpene, a trichothecene fusarium mycotoxin. J Nat Prod 77(1):188-192. ; DOI: 10.1021/np4008365; pubs.acs.org/doi/10.1021/np4008365 (OA)
Fruhmann, P; Skrinjar, P; Weber, J; Mikula, H; Warth, B; Sulyok, M; Krska, R; Adam, G; Rosenberg, E; Hametner, C; Frohlich, J (2014). Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin. Tetrahedron 70(34): 5260-5266.; DOI: 10.1016/j.tet.2014.05.064; www-1sciencedirect-1com-100137b9v0f53.pisces.boku.ac.at/science/article/pii/S0040402014007583
Fruhmann, P; Weigl-Pollack, T; Mikula, H; Wiesenberger, G; Adam, G; Varga, E; Berthiller, F; Krska, R; Hametner, C; Fröhlich, J (2014): Methylthiodeoxynivalenol (MTD): Insight into chemistry, structure and toxicity of thia-Michael adducts of trichothecenes. Organic & Biomolecular Chemistry 12: 5144-5150.; DOI: 10.1039/c4ob00458b ; dx.doi.org/10.1039/c4ob00458b (OA)
Gacek, A., Strauss, J., 2012. The chromatin code of fungal secondary metabolite gene clusters. Appl Microbiol Biotechnol 95, 1389-1404. DOI: 10.1007/s00253-012-4208-8. www.ncbi.nlm.nih.gov/pubmed/22814413
Gacek-Matthews, A., Berger, H., Sasaki, T., Wittstein, K., Gruber, C., Lewis, Z.A., Strauss, J., 2016. KdmB, a Jumonji Histone H3 Demethylase, Regulates Genome-Wide H3K4 Trimethylation and Is Required for Normal Induction of Secondary Metabolism in Aspergillus nidulans. PLoS Genet 12, e1006222. DOI: 10.1371/journal.pgen.1006222. www.ncbi.nlm.nih.gov/pubmed/27548260
Gacek-Matthews, A., Noble, L.M., Gruber, C., Berger, H., Sulyok, M., Marcos, A.T., Strauss, J., Andrianopoulos, A., 2015. KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans. Mol Microbiol 96, 839-860. DOI: 10.1111/mmi.12977. www.ncbi.nlm.nih.gov/pubmed/25712266
Gardiner, SA; Boddu, J; Berthiller, F; Hametner, C; Stupar, R; Adam, G; Muehlbauer, GJ (2010): Transcriptome analysis of the barley-deoxynivalenol interaction: evidence for a role of glutathione in deoxynivalenol detoxification. Molecular Plant-Microbe Interactions 23: 962-976.; DOI: 10.1094/MPMI-23-7-0962; dx.doi.org/10.1094/MPMI-23-7-0962 (OA)
Hilscher, J Buerstmayr, H; Stoger, E. (2017) Targeted modification of plant genomes for precision crop breeding. Biotechnol. J. 12. ; DOI: 10.1002/biot.201600173;
Husar, S; Berthiller, F; Fujioka, S; Rozhon, W; Khan, M; Kalaivanan, F; Elias, L; Higgins, G S; Li, Y; Schuhmacher, R; Krska, R; Seto, H; Vaistij, F E; Bowles, D; Poppenberger, B (2011): Overexpression of the UGT73C6 alters brassinosteroid glucoside formation in Arabidopsis thaliana. BMC Plant Biology 11, 51.http://www.ncbi.nlm.nih.gov/pubmed/21429230
Kapusi, E. and Stoger, E. (2018) Detection of CRISPR/Cas9 induced genomic fragment deletions in barley and generation of homozygous edited lines via embryogenic pollen culture. Methods Mol. Biol. in press
Kapusi, E; Corcuera-Gómez, M; Melnik, S; Stoger, E. (2017) Heritable Genomic Fragment Deletions and Small Indels in the Putative ENGase Gene Induced by CRISPR/Cas9 in Barley. Front. Plant. Sci. 8, 540. ; DOI: 10.3389/fpls.2017.00540 ;
Kluger, B., Lehner, S.M., Schuhmacher, R (2015): Metabolomics and Secondary Metabolite Profiling of Filamentous Fungi. In: Zeilinger, S., J-F, M., Garcia-Estrada, C. (Eds.) Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 Springer, New York, Heidelberg, Dordrecht, London. DOI: 10.1007/978-1-4939-2531-5 dx.doi.org/10.1007/978-1-4939-2531-5_6
Kluger, B., Zeilinger, S., Wiesenberger, G., Schöfbeck, D., and Schuhmacher, R. (2012). Detection and identification of fungal microbial volatile organic compounds by HS-SPME-GC-MS. In Laboratory Protocols in Fungal Biology: Current Methods in Fungal Biology, V.K. Gupta, M. Tuohy, M. Ayychamy, K.M. Turner, and O.D. A., eds. (Springer).
Kluger, B; Bueschl, C; Lemmens, M; Berthiller, F; Häubl, G; Jaunecker, G; Adam, G; Krska, R; Schuhmacher, R (2013): Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat. Anal Bioanal Chem 405(15): 5031-5036. DOI: dx.doi.org/10.1007/s00216-012-6483-8
Kluger, B; Bueschl, C; Lemmens, M; Michlmayr, H; Malachova, A; Koutnik, A; Maloku, I; Berthiller, F; Adam, G; Krska, R; Schuhmacher, R (2015): Biotransformation of the mycotoxin deoxynivalenol in fusarium resistant and susceptible near isogenic wheat lines. PLoS One 10(3): e0119656DOI: dx.doi.org/10.1371/journal.pone.0119656
Kluger, B; Bueschl, C; Neumann, NKN; Stückler, R; Doppler, M; Chassy, AW; Waterhouse, AL; Rechthaler, J; Kampleitner, N; Thallinger, GG; Adam, G; Krska, R; Schuhmacher, R (2014): Untargeted profiling of tracer-derived metabolites using stable isotopic labeling and fast polarity-switching LC-ESI-HRMS. Anal Chem 86(23): 11533-11537.; DOI: 10.1021/ac503290j ; dx.doi.org/10.1021/ac503290j (OA)
Koch, S; Bueschl, C; Doppler, M; Simader, A; Meng-Reiterer, J; Lemmens, M; Schuhmacher, R (2016): MetMatch: A Semi-Automated Software Tool for the Comparison and Alignment of LC-HRMS Data from Different Metabolomics Experiments. Metabolites 6(4): 39. ; DOI:10.3390/metabo6040039; www.mdpi.com/2218-1989/6/4/39 (OA)
Kovalsky-Paris, MP; Schweiger, W; Hametner, C; Stückler, R; Muehlbauer, GJ; Varga, E; Krska, R; Berthiller, F; Adam, G (2014): Zearalenone-16-O-glucoside: A New Masked Mycotoxin. J Agr Food Chem 62(5): 1181-1189. ; DOI: 10.1021/jf405627d; dx.doi.org/10.1021/jf405627d (OA)
Krska, R; Schuhmacher, R (2013): Determination of mycotoxins. New Food Magazine 16: 43-46; ISSN 1461-4642.
Krska, R; Sulyok, M; Berthiller, F; Schuhmacher, R (2017): Mycotoxin testing: From Multi-toxin analysis to metabolomics. JSM Mycotoxins, 67 (1), 1-6; ISSN 0285-1466. DOI: dx.doi.org/10.2520/myco.671-8
Kugler, K. G; Siegwart, G; Nussbaumer, T; Ametz, C; Spannagl, M; Steiner, B; Schweiger, W (2013). Quantitative trait loci-dependent analysis of a gene co-expression network associated with Fusarium head blight resistance in bread wheat (Triticum aestivum L.). BMC Genomics, 14:728. ; DOI: 10.1186/1471-2164-14-728; dx.doi.org/10.1186/1471-2164-14-728 (OA)
Kugler, KG; Jandric, Z; Beyer, R; Klopf, E; Glaser, W; Lemmens, M; Shams, M; Mayer, K; Adam, G; Schuller, C (2016): Ribosome quality control is a central protection mechanism for yeast exposed to deoxynivalenol and trichothecin. BMC Genomics 17:417.; DOI: 10.1186/s12864-016-2718-y; bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2718-y (OA)
Kugler, KG; Siegwart, G; Nussbaumer, T; Ametz, C; Spannagl, M; Steiner, B; Schweiger, W (2013). Quantitative trait loci-dependent analysis of a gene co-expression network associated with Fusarium head blight resistance in bread wheat (Triticum aestivum L.). BMC Genomics, 14:728. ; DOI: 10.1186/1471-2164-14-728; dx.doi.org/10.1186/1471-2164-14-728 (OA)
Lang-Mladek C, Xie L, Nigam N, Chumak N, Binkert M, Neubert S, Hauser MT. UV-B signaling pathways and fluence rate dependent transcriptional regulation of ARIADNE12. Physiol Plant. 2012 Aug;145(4):527-39. doi: 10.1111/j.1399-3054.2011.01561.x.
Li, X; Michlmayr, H; Schweiger, W; Malachova, A; Shin, S; Huang, YD; Dong, YH; Wiesenberger, G; McCormick, S; Lemmens, M; Fruhmann, P; Hametner, C; Berthiller, F; Adam, G; Muehlbauer, GJ (2017): A barley UDP-glucosyltransferase inactivates nivalenol and provides Fusarium Head Blight resistance in transgenic wheat. J Exp Bot 68(9): 2187-2197.; DOI: 10.1093/jxb/erx109; dx.doi.org/10.1093/jxb/erx109 (OA)
Malachova, A; Stranska, M; Vaclavikova, M; Elliott, CT; Black, C; Meneely, J; Hajlova, J; Ezekiel, CN; Schuhmacher, R; Krska, R (2018): Advanced LC-MS-based methods to study the co-occurrence and metabolization of multiple mycotoxins in cereals and cereal-based food. Anal Bioanal Chem 410(3): 801-825. DOI: dx.doi.org/10.1007/s00216-017-0750-7
Meng-Reiterer, J; Bueschl, C; Rechthaler, J; Berthiller, F; Lemmens, M; Schuhmacher, R (2016): Metabolism of HT-2 Toxin and T-2 Toxin in Oats. Toxins 8(12). DOI: dx.doi.org/10.3390/toxins8120364
Meng-Reiterer, J; Varga, E; Nathanail, AV; Bueschl, C; Rechthaler, J; McCormick, SP; Michlmayr, H; Malachova, A; Fruhmann, P; Adam, G; Berthiller, F; Lemmens, M; Schuhmacher, R (2015): Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis. Anal Bioanal Chem 407(26): 8019-8033. DOI: dx.doi.org/10.1007/s00216-015-8975-9
Merz D, Richter J, Gonneau M, Sanchez-Rodriguez C, Eder T, Sormani R, Martin M, Hématy K, Höfte H, Hauser MT. T-DNA alleles of the receptor kinase THESEUS1 with opposing effects on cell wall integrity signaling. J Exp Bot. 2017 Jul 20;68(16):4583-4593. doi: 10.1093/jxb/erx263.
Michlmayr, H; Varga, E; Malachová, A; Fruhmann, P; Piątkowska, M; Hametner, C; Sovrova, J; Lemmens, M; Berthiller, F; Adam, G (2018): UDP-Glucosyltransferases from Rice, Brachypodium and Barley: Substrate Specificities and Synthesis of Type A and B Trichothecene-3-O-β-D-glucosides. Toxins 10, E111. DOI: dx.doi.org/10.3390/toxins10030111 (OA)
Michlmayr, H; Malachova, A; Varga, E; Kleinova, J; Lemmens, M; Newmister, S; Rayment, I; Berthiller, F; Adam, G (2015): Biochemical Characterization of a Recombinant UDP-glucosyltransferase from Rice and Enzymatic Production of Deoxynivalenol-3-O-beta-D-glucoside. Toxins 7(7): 2685-2700.; DOI: 10.3390/toxins7072685; dx.doi.org/10.3390/toxins7072685 (OA)
Michlmayr, H; Varga, E; Lupi, F; Malachova, A; Hametner, C; Berthiller, F; Adam, G (2017): Synthesis of Mono- and Di-Glucosides of Zearalenone and alpha-/beta-Zearalenol by Recombinant Barley Glucosyltransferase HvUGT14077. TOXINS 9(2).; DOI: 10.3390/toxins9020058 ; www.mdpi.com/2072-6651/9/2/58/htm (OA)
Michlmayr, H; Varga, E; Malachová, A; Fruhmann, P; Piątkowska, M; Hametner, C; Šofrová, J; Jaunecker, G; Häubl, G; Lemmens, M; Berthiller, F; Adam, G;(2018): UDP-Glucosyltransferases from Rice, Brachypodium, and Barley: Substrate Specificities and Synthesis of Type A and B Trichothecene-3-O-β-d-glucosides..Toxins (Basel): 10(3).; DOI: 10.3390/toxins10030111; dx.doi.org/10.3390/toxins10030111 (OA)
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