We study metabolism, cell biology and biodiversity of methylotrophic yeasts. Yeasts of the Komagataella genus (formerly known as Pichia pastoris) entered the stage as bioproduction hosts, however they also make excellent models to study non canonical metabolic pathways, evolution of metabolism and species formation. We engineer their metabolism to enable the utilization of alternative substrates (even carbon dioxide) or the production of new compounds like organic acids and heterologous proteins and we develop tailored production processes. In addition we study the genetic diversity of the Komagataella genus, and investigate the regulation of carbon metabolism.

Metabolic Engineering

Cell and Process Engineering

Genome Diversity

Pichia Genome Database

This database hosts up-to-date annotation information of the genome of the methylotrophic yeast Pichia pastoris (Komagataella spp.), containing the new manually achieved annotation of K. phaffii strain CBS7435, and basic sequence and annotation information taken from the GenBank data of various Komagataella strains and species.
Additionally the sequence information of S. cerevisiae strain S288c is also available for comparison and homolog display.

Latest Publication

A subcellular proteome atlas of the yeast Komagataella phaffii. (2020) Valli M, Grillitsch K, Grünwald-Gruber C, Tatto NE, Hrobath B, Klug L, Ivashov V, Hauzmayer S, Koller M, Tir N, Leisch F, Gasser B, Graf AB, Altmann F, Daum G, Mattanovich D. FEMS Yeast Res. 2020 Feb 1;20(1). pii: foaa001. doi: 10.1093/femsyr/foaa001.

Publication in Nature Biotech

The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2. (2019) Gaßler, T., Sauer M., Gasser B., Egermeier M., Troyer Ch., Causon T., Hann St., Mattanovich D., Steiger M. Nature Biotechnology doi.org/10.1038/s41587-019-0363-0

Diethard Mattanovich, Univ.Prof. Dipl.-Ing. Dr.nat.techn.

H79200 Institut für Mikrobiologie und Mikrobielle Biotechnologie
H79000 Department für Biotechnologie (DBT)

+43 1 47654-79042
+43 1 47654-79009
Institut für Mikrobiologie und Mikrobielle Biotechnologie
Muthgasse 18/V
1190 Wien
Muthgasse 18
1190 Wien