Mattanovich Lab: Metabolic and Cell Engineering

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We study metabolism, cell biology and biodiversity of methylotrophic yeasts. Yeasts of the Komagataella genus (formerly known as Pichia pastoris) entered the stage as bioproduction hosts, however they also make excellent models to study non canonical metabolic pathways, evolution of metabolism and species formation. We engineer their metabolism to enable the utilization of alternative substrates (even carbon dioxide) or the production of new compounds like organic acids and heterologous proteins and we develop tailored production processes. In addition we study the genetic diversity of the Komagataella genus, and investigate the regulation of carbon metabolism.

Metabolic Engineering

Cell and Process Engineering

Genome Diversity

Pichia Genome Database

This database hosts up-to-date annotation information of the genome of the methylotrophic yeast Pichia pastoris (Komagataella spp.), containing the new manually achieved annotation of K. phaffii strain CBS7435, and basic sequence and annotation information taken from the GenBank data of various Komagataella strains and species.
Additionally the sequence information of S. cerevisiae strain S288c is also available for comparison and homolog display.

Zur Applikation

http://www.pichiagenome.org

Publications of this Research Group

Video über jüngste Forschungserfolge

3 Fragen an Diethard Mattanovich

erstellt vom BOKU Team für Öffentlichkeitsarbeit

New Publication

The secretome of Pichia pastoris in fed-batch cultivations is largely independent of the carbon source but changes quantitatively over cultivation time.

Burgard J, Grünwald-Gruber C, Altmann F, Zanghellini J, Valli M, Mattanovich D, Gasser B. (2019) Microb Biotechnol. 2019 Nov 6. doi: 10.1111/1751-7915.13499.

Latest Publication

A subcellular proteome atlas of the yeast Komagataella phaffii. (2020) Valli M, Grillitsch K, Grünwald-Gruber C, Tatto NE, Hrobath B, Klug L, Ivashov V, Hauzmayer S, Koller M, Tir N, Leisch F, Gasser B, Graf AB, Altmann F, Daum G, Mattanovich D. FEMS Yeast Res. 2020 Feb 1;20(1). pii: foaa001. doi: 10.1093/femsyr/foaa001.