About the Stadlmann Lab

In our lab we explore the fundamental biological roles of protein glycosylation—the process of attaching sugar molecules to proteins—which drives key cellular processes such as signal transduction, cell adhesion, and intracellular trafficking. 

Developing advanced glycoproteomics technologies, we investigate the dynamic and site-specific glycosylation of proteins, uncovering how these modifications shape protein function and mediate interactions between cells and their environment. By decoding the complexity of the glycoproteome, we aim to address broader biological questions about how glycosylation regulates cellular communication, development, and adaptation across diverse systems. 

In addition to cutting-edge research, our lab is deeply committed to education and training. We understand our lab as a place for teaching practical skills in biochemical techniques and methods, offering students hands-on lab experience in curiosity-driven research projects, at all levels. By guiding students through their own projects, we provide them with the opportunity to explore grow as independent and innovative scientists.

Our working areas are:

Topics for Master and Bachelor thesis

can be found in the areas

-  Generation of novel glyco-vaccines
-  Isomer-specific glycan analysis by mass spectrometry
-  Investigation of the novel N-glycan structures of food additive algae
-  Glycoproteins in allergy diagnosis

Selected Publications

  1. Helm J, Mereiter S, Oliveira T, Gattinger A, Markovitz DM, Penninger JM, Altmann F, Stadlmann J., Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice Nat Commun. 2024 Nov 9;15(1):9725. doi: 10.1038/s41467-024-54134-z.
  2. Stadlmann J, Taubenschmid J, Wenzel D, Gattinger A, Dürnberger G, Dusberger F, Elling U, Mach L, Mechtler K, Penninger JM., Comparative glycoproteomics of stem cells identifies new players in ricin toxicity Nature. 2017 Sep 28;549(7673):538-542. doi: 10.1038/nature24015. Epub 2017 Sep 20.
  3. Taubenschmid J, Stadlmann J, Jost M, Klokk TI, Rillahan CD, Leibbrandt A, Mechtler K, Paulson JC, Jude J, Zuber J, Sandvig K, Elling U, Marquardt T, Thiel C, Koerner C, Penninger JM., A vital sugar code for ricin toxicity Cell Res. 2017 Nov;27(11):1351-1364. doi: 10.1038/cr.2017.116. Epub 2017 Sep 19.
  4. Stadlmann J, Hoi DM, Taubenschmid J, Mechtler K, Penninger JM., Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities Proteomics. 2018 Jul;18(13):e1700436. doi: 10.1002/pmic.201700436. Epub 2018 Jun 10.
  5. Wirnsberger G, Zwolanek F, Stadlmann J, Tortola L, Liu SW, Perlot T, Järvinen P, Dürnberger G, Kozieradzki I, Sarao R, De Martino A, Boztug K, Mechtler K, Kuchler K, Klein C, Elling U, Penninger JM., Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense Nat Genet. 2014 Sep;46(9):1028-33. doi: 10.1038/ng.3070. Epub 2014 Aug 17.
  6. Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, Busslinger M, Bergthaler A, Klein C, Penninger JM., A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans J Exp Med. 2021 Jan 4;218(1):e20200559. doi: 10.1084/jem.20200559.
  7. Raglow Z, McKenna MK, Bonifant CL, Wang W, Pasca di Magliano M, Stadlmann J, Penninger JM, Cummings RD, Brenner MK, Markovitz DM., Targeting glycans for CAR therapy: The advent of sweet CARs Mol Ther. 2022 Sep 7;30(9):2881-2890. doi: 10.1016/j.ymthe.2022.07.006. Epub 2022 Jul 12.
  8. Capraz T, Kienzl NF, Laurent E, Perthold JW, Föderl-Höbenreich E, Grünwald-Gruber C, Maresch D, Monteil V, Niederhöfer J, Wirnsberger G, Mirazimi A, Zatloukal K, Mach L, Penninger JM, Oostenbrink C, Stadlmann J., Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor Elife. 2021 Dec 20;10:e73641. doi: 10.7554/eLife.73641.
  9. Yan S, Vanbeselaere J, Ives C, Stenitzer D, Nuschy L, Wöls F, Paschinger K, Fadda E, Stadlmann J, Wilson IBH. Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells. Mol Cell Proteomics. 2025 May 5;24(6):100981. doi: 10.1016/j.mcpro.2025.100981. Epub ahead of print. PMID: 40334746; PMCID: PMC12166434.
  10. Walcher S, Hager-Mair FF, Stadlmann J, Kählig H, Schäffer C., Deciphering fucosylated protein-linked O-glycans in oral Tannerella serpentiformis: Insights from NMR spectroscopy and glycoproteomics Glycobiology. 2024 Dec 10;34(12):cwae072. doi: 10.1093/glycob/cwae072.