894404 Basic course IV - bioinformatics and molecular modelling (in Eng.)


Art
Vorlesung
Semesterstunden
2
Vortragende/r (Mitwirkende/r)
Ludwig, Roland , Oostenbrink, Chris , Tscheließnig, Rupert , Zanghellini, Jürgen
Organisation
Angeboten im Semester
Sommersemester 2020
Unterrichts-/ Lehrsprachen
Englisch

Lehrinhalt

Part A: Bioinformatics

Data bases and data mining
Genome and gene analysis
Functional annotation of genes
Phylogenetics
Microarray analysis I: Experimental design
Microarray analysis II: Data processing and quality control
Multivariate data analysis
New techniques and trends in computational genomcs
Computational proteomics
Biostatistics

Part B: Molecular Modeling
Protein structure databases
Protein modeling I: Homology models and analysis of structural features
Protein modeling II: Domain analysis and functional annotation
Protein modeling III: In sillico mutagenesis and protein design
Structure-based drug design
In silico target discovery and lead finding
Molecular simulation of protein-ligand interactions
Mass transfer properties of biomolecules
Modelling of protein chromatography

Lehrziel

Knowledge on how to use relevant tools of bioinformatics and molecular modling in all steps of production of recombinant proteins, ranging from genome and gene analysis, expression profiling, genomic and postgenomic technology platforms, data acquisition, analysis and interpretation. Ability to link the biophysical properties of proteins with design strategies for protein production and purification.
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