940002 RNA Biology (in Eng.)

Vortragende/r (Mitwirkende/r)
Kalyna, Mariya
Angeboten im Semester
Sommersemester 2022
Unterrichts-/ Lehrsprachen


RNA is a fascinating molecule, and, in this course, we will look at the mechanisms that underlie its synthesis, processing, and turnover. We aim to understand the diverse roles for RNA in cellular life and in physiology, development and disease of eukaryotic organisms. Topics will also include RNA-based applications, from RNA interference and the CRISPR/Cas9 system to RNA therapeutics. This lecture course will cover:
-RNA-binding proteins
-Pre-mRNA processing
-Pre-mRNA splicing and regulated alternative splicing
-RNA splicing in development, stress response, and disease
-RNA traffic and localization
-mRNA translation
-RNA turnover (stability and degradation)
-RNA editing, modifications and the epitranscriptome
-Long and short noncoding RNAs

Inhaltliche Voraussetzungen (erwartete Kenntnisse)

Basic knowledge of molecular biology.
The course is open to students at the bachelor, master’s and other levels.


The student should:
-have theoretical knowledge of major aspects of RNA biology
-understand why and how RNA biology could be applied in basic research
-understand RNA-based approaches in elucidating gene function, manipulating gene activity, and therapeutic potential of RNA

The student should understand scientific literature on RNA biology. Students should learn information and concepts that they can use as future professionals.

General competence
The student should communicate what RNA molecules are, why it is important to investigate RNA, and how studies can be designed and performed.
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