790356 Metabolic and cell engineering (in Eng.)

Art
Vorlesung
Semesterstunden
2
Vortragende/r (Mitwirkende/r)
Organisation
Angeboten im Semester
Sommersemester 2023
Unterrichts-/ Lehrsprachen
Englisch
Lehrinhalt

Summary and update of cellular metabolism: catabolism and anabolism, energy conversion, reduction and oxidation equvalents.
Balances and equations describing cellular processes: mass, energy, redox and carbon balances; basic models to describe cells.
Application of metabolic modelling for metabolic and cell engineering.
Systems biology: describing the complexity of cellular systems.
Methods: metabolic flux analysis, metabolomics, transcriptomics, quantitative proteomics.
Tools for metabolic and cell engineering.
Major biotechnological challanges: New metabolic pathways leading to new products. Microbial stress during production. Protein secretion.
Applications of metabolic engineering: overproduction of metabolites with microorganisms.
Applications of cell engineering: improving cellular properties, e.g. secretion of recombinant proteins, strain robustness (stress resistance).
Inhaltliche Voraussetzungen (erwartete Kenntnisse)

Biochemistry and cellular physiology. Metabolic pathways and metabolic regulation. Metabolic modelling.
Lehrziel

Students are familiar with principles of designing metabolic and cell engineering projects.
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