790393 Antibodies and beyond - emerging fields in antibody engineering (in Eng.)

Art
Vorlesung und Seminar
Semesterstunden
2
Vortragende/r (Mitwirkende/r)
Wick, Cecilia , Wozniak-Knopp, Gordana
Organisation
Biotechnologie und Lebensmittelwissenschaften
Angeboten im Semester
Sommersemester 2025
Unterrichts-/ Lehrsprachen
Englisch
Lehrinhalt

An introductory as well as organisational meeting for this lecture-seminar will be held on March 4, 2025, at 10 AM via Zoom:

Join Zoom Meeting:
https://bokuvienna.zoom.us/j/63703325835?pwd=edUu9TZpOZwyvSArQamftmxCaZKfNB.1

The seminars will be held in person on the 3rd of June, from 9-17h, in the small seminar room on the 5th floor of DBT in the building Muthgasse1 (MUGI /05-10, also called SR 52).


Each unit will consist of a seminar and extensive discussion as well as lecture selected topics, which will be listed on BOKU learn.
The presentations are planned for 15 min with 5 min discussion. The structure: please study the topic and fell supported with the literature provided, but you are not restricted or bound to it. You are welcome to propose and present your own topics, only please share your thoughts with us ahead of the presentation.
Proposed topics:

- Good Deal with DLL (Bispecifics and CAR-T cells targeting DLL3 in cancer)
- LEGO for antibody engineers(Multiple building block antibodies to combat acute myeloid leukemia)
- The roof is on fire (Antibodies in type 2 inflammation (atopic dermatitis and COPD) – Stapokibart)
- Her mit der Leberkässemmel (PCSK9-targeting antibodies lowering cholesterol)
- ENRGy! (Bispecific Her2/Her3 antibodies effective in tumors with NRG1 rearrangements)
- 2 to boo Her2 (Superstable biparatopic anti-Her2 antibodies)
- A new handbag to fit your drugs in (Antibody-displaying extracellular vesicles (EVs) for targeted cancer therapy)
- Molecular Trojan horse (Bispecific antibody shuttles CD98hc_LAT1 to transport IgG in the brain)
- You can have an automatic Tesla! (First fully human CAR T-cells for use in autoimmune disorders)
- 5 ants are better than 4 elephants (Fully human single domain antibody as therapy)
- A fitted designer dress is never wrong (i-shaped antibody engineering)
- Why select when you can have both? (Hybrid immunity for SARS-CoV-2)
- Cooler than vegan steaks (Vegan antibodies)
Inhaltliche Voraussetzungen (erwartete Kenntnisse)

The following lectures are highly recommended:

941105 Introduction to Molecular Biology (in Eng.)
772304 Protein chemistry and protein engineering (in Eng.)
791397 Protein engineering (in Eng.)
941319 Cell and molecular biology I (in Eng.)
791368 Biological Therapeutics (in Eng.)
791398 Antibody Engineering (in Eng.)
Lehrziel

Successful participants will be able to:
-give an overview of the current situation in the antibody engineering field, including current most successful antibody-based therapies and future trends
-comment on the various classes of targets of therapeutic antibodies in the last decades
-compare the mode of activity of various therapeutic antibodies
-defend the importance of armoured antibodies (ADCs, CARs)
-outline the differentiation of bispecific antibodies and Fc fusions
- communicate their views to peers (colleagues) in a constructive discussion
- cooperate with colleagues in delivery and evaluation of individual presentations
Noch mehr Informationen zur Lehrveranstaltung, wie Termine oder Informationen zu Prüfungen, usw. finden Sie auf der Lehrveranstaltungsseite in BOKUonline.