773311 Introduction into crystallography and NMR spectroscopy of proteins (in Eng.)
- Art
- Vorlesung
- Semesterstunden
- 2
- Vortragende/r (Mitwirkende/r)
- Pfanzagl, Vera , Blaukopf, Markus , Heuser, Thomas
- Organisation
- Organische Chemie
- Angeboten im Semester
- Sommersemester 2025
- Unterrichts-/ Lehrsprachen
- Englisch
- Lehrinhalt
-
X-ray Crystallography:
Structural features of amino acids, peptides and proteins
Theory of protein crystallization and x-ray diffraction
Basics of X-ray data collection, processing, and model building
Current advances
Nuclear magnetic resonance (NMR):
Principles of one und multidimensional NMR
Protein NMR strategies
Labelling strategies
Protein-Ligand Interactions
Cryo-Electron Microscopy:
Vitrification methods
Single particle analysis
Cryo-electron tomography
Radiation damage in cryo-EM
- Inhaltliche Voraussetzungen (erwartete Kenntnisse)
-
Basic knowledge of biochemistry and spectroscopy. The lecture is recommended for advanced master study students and PhD students
.
- Lehrziel
-
The students will be able to explain the basics of structural biology and protein structure determination methods. The students will be able to compare the advantages/disadvantages of the main methods for structure determination. In particular, the students will be able to independently assess the quality and reliability of published protein structural data and protein models and use the obtained knowledge in discussing scientific publications.
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