790351 Cell factories (in Eng.)

Art
Vorlesung
Semesterstunden
3
Vortragende/r (Mitwirkende/r)
Machado Ferreira Castilho, Alexandra , Mattanovich, Diethard , Buyel, Johannes , Kunert, Renate
Organisation
Angeboten im Semester
Wintersemester 2024/25
Unterrichts-/ Lehrsprachen
Englisch
Lehrinhalt

Principles of product formation in cellular systems: transport of substrates and products, molecular mass, energy and redox balances, kinetics of product formation

Classical microbiological products as biomass, alcohols, acids

Secondary metabolites from microorganisms

Recombinant proteins expressed in bacteria, yeasts, filamentous fungi and animal cells

Preservation of microbial strains and cell lines, cell banking

Metabolic and cell engineering: principles, optimization of metabolic pathways; novel pathways

General cell-culture, cultivation

Cell culture systems for the production of recombinant proteins

Monoclonal antibodies

Viral expression vectors; transient expression

Plant cell cultures and methods of cultivation

Secondary metabolites form plants

Viral expression vectors for plants

Recombinant proteins expressed in plants; molecular pharming, edible vaccines

General virology, virus vaccines

Viruses, virus-proteins; recombinant vaccines
Lehrziel

After having passed this course the students are able to analyse the challenge for the production of different products in biological systems. They can determine the advantages of different cellular systems, and integrate their scientific knowledge into various levels of the production line. They are able to design strategies for reseach and development and assess needs and application potential of products.
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