We focus on the microbial conversion of CO2 and CO2-derived carbon substrates like methanol and formate using the methylotrophic yeast Komagataella phaffii (formerly known as Pichia pastoris), to explore the potential of these C1 sources as future feedstocks for sustainable bioprocesses. By combining metabolic modeling with engineering approaches, we aim to develop synthetic and native C1-utilization pathways and redesign cellular metabolism. We employ instationary 13C metabolic flux analysis (MFA) to map intracellular flux distributions and pinpoint metabolic bottlenecks for strain improvement. In addition, we study the energy and carbon metabolism to explore the interplay between interconnected metabolic routes and unravel underlying regulatory mechanisms.

Özge Ata, Dr. M.Sc.

Senior Scientist
Institut für Mikrobiologie und Mikrobielle Biotechnologie
Email
oezge.ata@boku.ac.at
Telefon
+43 1 47654-79038, 79046
Postadresse
Mikrobiologie und Mikrobielle Biotechnologie
Muthgasse 18/V
1190 Wien
Büro
MUG1-04/52
Muthgasse 18/IV
1190 Wien
Özge Ata
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