Synthesis of novel phenolic antioxidants and studies of their antioxidative action
Design of multi-functional stabilizers for polymers
Synthesis of novel vitamin E (tocopherol) derivatives with medical applications
Design of novel stabilizers based on vitamin E for application as antioxidants in plastics, food packaging and polymers for medical use
Experimental, theoretical and computational studies of antioxidative action EPR and spin trapping studies
Clarification of reaction mechanisms and metabolic pathways of vitamin E derivatives
Ubiquinol / ubiquinon derivatives and related compounds
Key publications:
Rosenau, T.; Potthast, A.; Ebner, G.; Hofinger, A.; Kosma, P. Org. Lett.2002, 4(8), 1257-1258. Novel Tocopheryl Compounds XII. On a novel chromanone - naphthalenetrione rearrangement related to vitamin E chemistry.
Rosenau, T.; Adelwöhrer, C.; Hofinger, A.; Mereiter, K.; Kosma, P. Eur. J. Org. Chem.2004, 6, 1323-1329. Novel tocopheryl compounds XVII. 3-Tocopherylisoxazolines by [2+3]-cycloaddition.
Adelwöhrer, C.; Rosenau, T.; Kosma, P. Tetrahedron 2003, 59(41), 8177-8182. Novel Tocopheryl Compounds XVI. Nitration of a-Tocopheryl Acetate – a Mechanistic Study.
Rosenau, T.; Adelwöhrer, C.; Hofinger, A.; Mereiter, K.; Kosma, P. Eur. J. Org. Chem.2004, 6, 1323-1329. Novel Tocopheryl Compounds XVII. 3-Tocopheryl-isoxazolines by [2+3]-Cycloaddition.
Staniek, K.; Rosenau, T.; Gregor, W.; Nohl, H.; Gille. L. Biochem. Pharmacol.2005, 70, 1361–1370. The protection of bioenergetic functions in mitochondria by new synthetic chromanols.
Adelwöhrer, C.; Rosenau, T.; Kloser, E.; Mereiter, K.; Netscher, T. Eur. J. Org. Chem. 2006, 9, 2081-2086. Novel Tocopheryl Compounds XXIII. Synthesis of 5a-a-tocopheryl azide and its reaction to 1-(5a-a-tocopheryl)-1,2,3-triazols by [2+3]-cycloaddition.
Patel, A.; Liebner, F.; Netscher, T.; Mereiter, K.; Rosenau, T. J. Org. Chem.2007, 72(17), 6504-6512. Nitration of non-alpha tocopherols – products and mechanistic considerations.
Gille, L.; Stamberg, W.; Jäger, W.; Reznicek, G.; Netscher, T.; Rosenau, T. Chem. Res. Toxicol. 2007, 20(4), 591-599. A new ubiquinone metabolite and its activity at the mitochondrial bc1 complex.
