Research

Within the framework of a literature study and a compact, experimental analysis, we summarize the data on particulate abrasions of ceramic dental implants and relate the result to the known data of conventional titanium implants. Expert interviews will be conducted within the framework of the project and thus a comprehensive picture of the evaluation and selection criteria of implant materials will be published as part of an overview study.

The basis for our technology is the so-called inline holography microscopy. We shine coherent light through a transparent volume with microscopic objects like bacteria, spores, algae, microplastics, etc. in it. These objects scatter a small amount of this light. The scattered light interferes with the illumination beam, creating interference patterns that are recorded by a camera. The breakthrough technology to be further developed in this project uses recorded in-line holograms to calculate the full light field in the entire sample volume by backpropagation or numerical refocusing. This offers several advantages: 1. the ability to numerically refocus after image acquisition greatly simplifies data acquisition. 2. cells and environmental particles can be observed in their natural 3D environment. 3. it is possible to observe many more objects simultaneously than is possible with conventional microscopy, and it is possible to record a continuous flow of an analyzed fluid. Based on the data collected with this technology, Holloid aims to develop algorithms that will allow researchers and environmental analysts to simultaneously detect and quantify bacteria and microparticles using a microscope/sensor suitable for environmental monitoring, including groundwater. This will provide a new means for those responsible for water quality in the environment and, ultimately, in drinking water to gain insights with significant implications for the health of our ecosystems and people. Ultimately, the results of this project can form the basis for numerous other applications in environmental monitoring and beyond.

Spread and progression of the tumour plays a crucial role, through the dynamic overlap between tumour cells and the extracellular matrix. CARES brings together leading academic and non-academic experts in the fields of matrix biology, biomaterials, microfluidics and cancer research to provide an accurate tool for assessing the response of cancer cells to a variety of anticancer drugs. As a proof-of-concept, we will use breast cancer cells as a model system, with the prospect of extending the system to other cancers. extending the system to other cancers. Our ultimate goal is to develop a novel and user-friendly platform that mimics the human tumour microenvironment in early and advanced stages of cancer by resembling the human tumour microenvironment in early and advanced stages of cancer and can predict with unprecedented accuracy the response of tumour cells to response of tumour cells to cancer therapies in vivo. This will facilitate the development and testing of new drugs and narrow the gap between translational cancer research and targeted cancer therapy, which will have a significant impact on society and the economy. The ambitious scientific goal will provide the backdrop for intensive cross-sectoral and interdisciplinary training of young scientists, providing them with an excellent translational research portfolio that will enable them to succeed in both academia and industry.