Genome editing holds significant promise for addressing persistent food insecurity in Africa, particularly through improved management of pests and diseases. Our research focuses on conferring resistance in cereal crops to Striga, a parasitic weed that infests an estimated 40 million hectares of farmland and threatens the livelihoods of over 300 million smallholder farmers across sub-Saharan Africa.
Our approach targets the biochemical communication between host crops and the parasite by redirecting metabolite flux. Central to this strategy are strigolactones (SLs)—plant hormones secreted by roots to attract beneficial soil microbes. Unfortunately, these same molecules also stimulate Striga seed germination, triggering its parasitic lifecycle.
Building on a validated model in sorghum—where a mutation in a key strigolactone biosynthesis gene shifts production from the highly potent 5-deoxystrigol to the less active orobanchol—we have extended this genome editing strategy to other staple cereals, including maize, rice, and millets. Our development of gene-edited, Striga-resistant sorghum demonstrates both proof of concept and the potential for broader application across crops and regions.
However, translating such scientific breakthroughs into tangible agricultural impact requires more than laboratory innovation. To position Africa for early and sustained success in agricultural genome editing, several critical components must be in place: strengthened local scientific capacity and infrastructure, supportive and efficient regulatory frameworks, responsible stewardship and licensing practices, and clear, transparent communication with stakeholders. Together, these elements will enable the development, adoption, and commercialization of home-grown genome-edited crops—driving the transformation of food systems across the continent.
Keywords: Gene-Edited Crops, Regulatory Readiness, Technology Adoption
Event location: Gregor Mendel Str. 33, Vienna, Room: MENH-01/26 = HS 11 / MENH [HS IX]
