772304 Protein chemistry and protein engineering (in Eng.)
- Art
- Vorlesung und Übung
- Semesterstunden
- 3
- Vortragende/r (Mitwirkende/r)
- Organisation
- Angeboten im Semester
- Sommersemester 2024
- Unterrichts-/ Lehrsprachen
- Englisch
- Lehrinhalt
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THEORETICAL PART - LECTURES
The theoretical parts might not be presented in this order!
Unit 1: Historical perspective, Therapeutic use of antibodies, Evolution in nature and in the lab: ZAJC
Unit 2: Forces between molecules, Protein structures: ZAJC
Unit 3: Thermodynamics of protein folding and unfolding: ZAJC
Unit 4: Real-world examples for recent advances in protein engineering: ZAJC
Unit 5: Mutagenesis strategies I: PETERBAUER
Unit 6: Mutagenesis strategies II: PETERBAUER
Unit 7: Protein libraries: WOZNIAK-KNOPP
Unit 8: Surface Display: WOZNIAK-KNOPP
Unit 9: Protein dynamics and molecular dynamics simulations: OOSTENBRINK
Unit 10: Functional studies on proteins I: Enzyme kinetics (steady-state versus presteady kinetics): FURTMÜLLER
Unit 11: Functional studies on proteins II: Ligand binding and protein-protein interaction (surface plasmon resonance, biolayer interferometry ect.): FURTMÜLLER
PRACTICAL PART:
Databases and phylogeny: LUDWIG
Protein structure modeling and prediction: OOSTENBRINK
- Inhaltliche Voraussetzungen (erwartete Kenntnisse)
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Basic lectures in Organic Chemistry, Biochemistry and Molecular Biology
- Lehrziel
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After completing this course and passing the exam students should understand the relationship between protein structure and function as well as protein dynamics and stability. Moreover they will have an overview about the most important techniques in elucidation of protein structure and quality. The principles in protein design and engineering will be discussed as well as the use of the most important databases, elucidation of protein phylogeny. Further, students will gain insight into the basics in protein modeling and structure prediction.
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