Publications

Concept of stable isotope labelling studies:

Bueschl, C., R. Krska, B. Kluger and R. Schuhmacher (2013). "Isotopic labeling-assisted metabolomics using LC–MS." Analytical and Bioanalytical Chemistry 405(1): 27-33.

Workflow for global metabolome labelling experiments:

Bueschl, C., B. Kluger, M. Lemmens, G. Adam, G. Wiesenberger, V. Maschietto, A. Marocco, J. Strauss, S. Bödi, G. Thallinger, R. Krska and R. Schuhmacher (2014). "A novel stable isotope labelling assisted workflow for improved untargeted LC–HRMS based metabolomics research." Metabolomics 10(4): 754-769.

Software for automated data evaluation:

Bueschl, C., B. Kluger, N. K. N. Neumann, M. Doppler, V. Maschietto, G. G. Thallinger, J. Meng-Reiterer, R. Krska and R. Schuhmacher (2017). "MetExtract II: A software suite for stable isotope assisted untargeted metabolomics." Analytical Chemistry 89(17): 9518-9526.

Study to investigate differences in the metabolome of diverse plant parts and comparison of extraction solvents on the metabolome:

Doppler, M., B. Kluger, C. Bueschl, C. Schneider, R. Krska, S. Delcambre, K. Hiller, M. Lemmens and R. Schuhmacher (2016). "Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants." International Journal of Molecular Sciences 17(7): 1017.

Production of ¹³C labelled plant material:

Ćeranić, A., M. Doppler, C. Büschl, A. Parich, K. Xu, A. Koutnik, H. Bürstmayr, M. Lemmens and R. Schuhmacher (2020). "Preparation of uniformly labelled 13C- and 15N-plants using customised growth chambers." Plant Methods 16(1): 46.

Mycotoxins in planta, food or mammalian cell cultures:

Kluger, B., C. Bueschl, M. Lemmens, F. Berthiller, G. Häubl, G. Jaunecker, G. Adam, R. Krska and R. Schuhmacher (2013). "Stable isotopic labelling-assisted untargeted metabolic profiling reveals novel conjugates of the mycotoxin deoxynivalenol in wheat." Analytical and Bioanalytical Chemistry 405(15): 5031-5036.

Kluger, B., C. Bueschl, M. Lemmens, H. Michlmayr, A. Malachova, A. Koutnik, I. Maloku, F. Berthiller, G. Adam, R. Krska and R. Schuhmacher (2015). "Biotransformation of the mycotoxin deoxynivalenol in fusarium resistant and susceptible near isogenic wheat lines." PLoS ONE 10(3).

Nathanail, A. V., E. Varga, J. Meng-Reiterer, C. Bueschl, H. Michlmayr, A. Malachova, P. Fruhmann, M. Jestoi, K. Peltonen, G. Adam, M. Lemmens, R. Schuhmacher and F. Berthiller (2015). "Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat." Journal of Agricultural and Food Chemistry 63(35): 7862-7872.

Meng-Reiterer, J., E. Varga, A. V. Nathanail, C. Bueschl, J. Rechthaler, S. P. McCormick, H. Michlmayr, A. Malachová, P. Fruhmann, G. Adam, F. Berthiller, M. Lemmens and R. Schuhmacher (2017). "Tracing the metabolism of HT-2 toxin and T-2 toxin in barley by isotope-assisted untargeted screening and quantitative LC-HRMS analysis." Analytical and Bioanalytical Chemistry 407(26).

Stadler, D., F. Lambertini, C. Bueschl, G. Wiesenberger, C. Hametner, H. Schwartz-Zimmermann, R. Hellinger, M. Sulyok, M. Lemmens, R. Schuhmacher, M. Suman, F. Berthiller and R. Krska (2019). "Untargeted LC–MS based 13C labelling provides a full mass balance of deoxynivalenol and its degradation products formed during baking of crackers, biscuits and bread." Food Chemistry 279: 303-311.

Flasch, M., C. Bueschl, L. Woelflingseder, H. E. Schwartz-Zimmermann, G. Adam, R. Schuhmacher, D. Marko and B. Warth (2020). "Stable Isotope-Assisted Metabolomics for Deciphering Xenobiotic Metabolism in Mammalian Cell Culture." ACS Chemical Biology 15(4): 970-981.

Phenylalanine in planta and cell cultures:

Kluger, B., C. Bueschl, N. Neumann, R. Stückler, M. Doppler, A. W. Chassy, A. L. Waterhouse, J. Rechthaler, N. Kampleitner, G. G. Thallinger, G. Adam, R. Krska and R. Schuhmacher (2014). "Untargeted profiling of tracer-derived metabolites using stable isotopic labeling and fast polarity-switching LC-ESI-HRMS." Analytical Chemistry 86(23): 11533-11537.

Doppler, M., C. Bueschl, B. Kluger, A. Koutnik, M. Lemmens, H. Buerstmayr, J. Rechthaler, R. Krska, G. Adam and R. Schuhmacher (2019). "Stable Isotope–Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation." Frontiers in Plant Science 10(1366).

Doppler, M., B. Kluger, C. Bueschl, B. Steiner, H. Buerstmayr, M. Lemmens, R. Krska, G. Adam and R. Schuhmacher (2019). "Stable Isotope-Assisted Plant Metabolomics: Investigation of Phenylalanine-Related Metabolic Response in Wheat Upon Treatment With the Fusarium Virulence Factor Deoxynivalenol." Frontiers in Plant Science 10(1137).

Visualizing methanol derived artifacts:

Sauerschnig, C., M. Doppler, C. Bueschl and R. Schuhmacher (2018). "Methanol Generates Numerous Artifacts during Sample Extraction and Storage of Extracts in Metabolomics Research." Metabolites 8(1): 1.

11. Glutathione from recovered glucose as ingredient in antioxidant nanocapsules for triggered flavor delivery. Claudia Tallian, Vanessa Rumpler, Lukas Skopek, Hannes Russmayer, Matthias G. Steiger, Robert Vielnascher, Simone Weinberger, Alessandro Pellis, Sara Vecchiato and Georg M. Guebitz. J. Mater. Chem. B, 2019,7, 3958-3969

10. Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules. Claudia Tallian, Alexandra Herrero-Rollett, Karina Stadler, Robert, Vielnascher, Karin Wieland, Anna M. Weihs, Alessandro Pellis, Andreas H. Teuschl, Bernhard Lendl, Heinz Amenitsch, Georg M.Guebitz. Eur. J. Pharm. Biopharm., 2018, 133,176-187

9. Laccase catalyzed elimination of morphine from aqueous systems. Daniela Huber, Klaus Bleymaier, Alessandro Pellis, Robert Vielnascher, Andreas Daxbacher, Katrin J Greimel, Georg M Guebitz. New Biotechnol., 2018, 42, 19-25

8. Ultrasound-assisted extraction of hemicellulose and phenolic compounds from bamboo bast fiber powder. Cheng Wang, Claudia Tallian, Jing Su, Robert Vielnascher, Carla Silva, Artur Cavaco-Paulo, Georg M. Guebitz, Jiajia Fu. Plos One, 2018, 13, e0197537

7. Enzymatic degradation of poly(ethylene 2,5-furanoate) powders and amorphous films. Simone Weinberger, Judit Canadell, Felice Quartinello, Bahar Yeniad, Andrea Arias, Alessandro Pellis*, Georg M. Guebitz. Catalysts, 2017, 7, 318

6. Superhydrophobic functionalization of cutinase activated poly (lactic acid) surfaces. Andreas Ortner, Alessandro Pellis, Caroline Gamerith, A. O. Yebra, Denis Scaini, Iwona Kaluzna, Daniel Mink, S de Wildeman, E Herrero Acero, GM Guebitz. Green Chem., 2017, 19, 816-822

5. Enzymatic hydrolysis of poly (ethylene furanoate). Alessandro Pellis*, Karolina Haernvall, Christian M Pichler, Gagik Ghazaryan, Rolf Breinbauer, Georg M Guebitz. J. Biotechnol., 2016, 235, 47-53

4. Cellobiohydrolases Produce Different Oligosaccharides from Chitosan. Gregor Tegl, Christoph Öhlknecht, Robert Vielnascher, Alexandra Rollett, Andreas Hofinger-Horvath, Paul Kosma, Georg M. Guebitz. Biomacromolecules, 2016, 17, 2284-2292

3. Improving enzymatic polyurethane hydrolysis by tuning enzyme sorption. Caroline Gamerith, Enrique Herrero Acero, Alessandro Pellis, Andreas Ortner, Robert Vielnascher, Daniel Luschnig, Barbara Zartl, Karolina Haernvall, Sabine Zitzenbacher, Gernot Strohmeier, Oskar Hoff, Georg Steinkellner, Karl Gruber, Doris Ribitsch, Georg M Guebitz. Polym. Degrad. Stabil., 2016, 132, 69-77

2. Commercial cellulases from Trichoderma longibrachiatum enable a large-scale production of chito-oligosaccharides. Gregor Tegl, Christoph Öhlknecht, Robert Vielnascher, Paul Kosma, Andreas Hofinger-Horvath and Geog M. Guebitz. Pure and Applied Chemistry, 2016, 88, 865-872

1. Fast Blue RR—Siloxane Derivatized Materials Indicate Wound Infection Due to a Deep Blue Color Development. Doris Schiffer, Gregor Tegl, Robert Vielnascher, Hansjoerg Weber, Rainer Schoeftner, Herfried Wiesbauer, Eva Sigl, Andrea Heinzle, Georg M. Guebitz. Materials, 2015, 8, 6633-6639.

Zangl I, Beyer R, Gattesco A, Labuda R, Pap IJ, Strauss J, Schüller C.
Limosilactobacillus fermentum Limits Candida glabrata Growth by Ergosterol
Depletion. Microbiol Spectr. 2023 Feb 21;11(2):e0332622. doi:
10.1128/spectrum.03326-22. Epub ahead of print. PMID: 36802215; PMCID:
PMC10100998.

Hollenstein DM, Gérecová G, Romanov N, Ferrari J, Veis J, Janschitz M, Beyer
R, Schüller C, Ogris E, Hartl M, Ammerer G, Reiter W. A phosphatase-centric
mechanism drives stress signaling response. EMBO Rep. 2021 Nov 4;22(11):e52476.
doi: 10.15252/embr.202152476. Epub 2021 Sep 24. PMID: 34558777; PMCID:
PMC8567219.

Labuda R, Bacher M, Gratzl H, Doppler M, Parich A, Aufy M, Lemmens-Gruber R,
Schuhmacher R, Rychli K, Wagner M, Rosenau T, Strauss J, Schüller C.
Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus
Metapochonia lutea. Molecules. 2021 Oct 30;26(21):6589. doi:
10.3390/molecules26216589. PMID: 34770997; PMCID: PMC8588484.

Ksiezopolska E, Schikora-Tamarit MÀ, Beyer R, Nunez-Rodriguez JC, Schüller C,
Gabaldón T. Narrow mutational signatures drive acquisition of multidrug
resistance in the fungal pathogen Candida glabrata. Curr Biol. 2021 Oct
21:S0960-9822(21)01352-X. doi: 10.1016/j.cub.2021.09.084. Epub ahead of print.
PMID: 34699784.

Labuda R, Bacher M, Rosenau T, Gasparotto E, Gratzl H, Doppler M, Sulyok M,
Kubátová A, Berger H, Cank K, Raja HA, Oberlies NH, Schüller C, Strauss J.
Polyphasic Approach Utilized for the Identification of Two New Toxigenic Members
of Penicillium Section Exilicaulis, P. krskae and P.
silybi spp. nov. J Fungi (Basel). 2021 Jul 13;7(7):557. doi:
10.3390/jof7070557. PMID: 34356936; PMCID: PMC8307998.

Zangl I, Beyer R, Pap IJ, Strauss J, Aspöck C, Willinger B, Schüller C. Human
Pathogenic Candida Species Respond Distinctively to Lactic Acid Stress. J
Fungi (Basel). 2020 Dec 8;6(4):348. doi: 10.3390/jof6040348. PMID: 33302409;
PMCID: PMC7762603.

Oufensou S, Balmas V, Azara E, Fabbri D, Dettori MA, Schüller C, Zehetbauer
F, Strauss J, Delogu G, Migheli Q. Naturally Occurring Phenols Modulate
Vegetative Growth and Deoxynivalenol Biosynthesis in Fusarium
graminearum ACS Omega. 2020 Nov 9;5(45):29407-29415. doi:
10.1021/acsomega.0c04260. PMID: 33225172; PMCID: PMC7676359.

Weinberger S, Beyer R, Schüller C, Strauss J, Pellis A, Ribitsch D, Guebitz
GM. High Throughput Screening for New Fungal Polyester Hydrolyzing Enzymes.
Front Microbiol. 2020 Apr 24;11:554. doi: 10.3389/fmicb.2020.00554. PMID:
32390956; PMCID: PMC7193820.

Labuda R, Bernreiter A, Hochenauer D, Schüller C, Kubátová A, Strauss J,
Wagner M. Saksenaea dorisiae sp. nov., a New Opportunistic Pathogenic
Fungus from Europe. Int J Microbiol. 2019 Sep 22;2019:6253829. doi:
10.1155/2019/6253829. PMID: 31662760; PMCID: PMC6778886.

Beyer R, Spettel K, Zeller I, Lass-Flörl C, Achleitner D, Krause R, Apfalter
P, Buzina W, Strauss J, Gregori C, Schüller C, Willinger B. Antifungal
susceptibility of yeast bloodstream isolates collected during a 10-year period
in Austria. Mycoses. 2019 Apr;62(4):357-367. doi: 10.1111/myc.12892. Epub 2019
Feb 20. PMID: 30636016.

Pfanzagl V, Görner W, Radolf M, Parich A, Schuhmacher R, Strauss J, Reiter W,
Schüller C. A constitutive active allele of the transcription factor Msn2
mimicking low PKA activity dictates metabolic remodeling in yeast. Mol Biol
Cell. 2018 Nov 15;29(23):2848-2862. doi: 10.1091/mbc.E18-06-0389. Epub 2018 Sep
26. PMID: 30256697; PMCID: PMC6249869.

Beyer R, Jandric Z, Zutz C, Gregori C, Willinger B, Jacobsen ID, Kovarik P,
Strauss J, Schüller C. Competition of Candida glabrata against Lactobacillus is
Hog1 dependent. Cell Microbiol. 2018 Dec;20(12):e12943. doi: 10.1111/cmi.12943.
Epub 2018 Sep 7. PMID: 30112857; PMCID: PMC6283251.

Fischer J, Müller SY, Netzker T, Jäger N, Gacek-Matthews A, Scherlach K,
Stroe MC, García-Altares M, Pezzini F, Schoeler H, Reichelt M, Gershenzon J,
Krespach MK, Shelest E, Schroeckh V, Valiante V, Heinzel T, Hertweck C, Strauss
J, Brakhage AA. Chromatin mapping identifies BasR, a key regulator of bacteria-
triggered production of fungal secondary metabolites. Elife. 2018 Oct
12;7:e40969. doi: 10.7554/eLife.40969. PMID: 30311911; PMCID: PMC6234034.

Zutz C, Wagener K, Yankova D, Eder S, Möstl E, Drillich M, Rychli K, Wagner
M, Strauss J. A robust high-throughput fungal biosensor assay for the detection
of estrogen activity. Steroids. 2017 Oct;126:57-65. doi:
10.1016/j.steroids.2017.07.005. Epub 2017 Jul 14. PMID: 28712952.

Cánovas D, Studt L, Marcos AT, Strauss J. High-throughput format for the
phenotyping of fungi on solid substrates. Sci Rep. 2017 Jun 27;7(1):4289. doi:
10.1038/s41598-017-03598-9. Erratum in: Sci Rep. 2020 Mar 6;10(1):4496. PMID:
28655890; PMCID: PMC5487330.