Selected publications

Heine, H., and Zamyatina, A. Therapeutic Targeting of TLR4 for Inflammation, Infection, and Cancer: A Perspective for Disaccharide Lipid A Mimetics. (2023) Pharmaceuticals 16, 23. doi: https://doi.org/10.3390/ph16010023

Borio, A., Holgado, A., Passegger, C., Strobl, H., Beyaert, R., Heine, H., and Zamyatina, A. (2023) Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids. Molecules 28, 5948. doi:https://doi.org/10.3390/molecules28165948

Strobl, S., Hofbauer, K., Heine, H., Zamyatina, A. Lipid A mimetics based on unnatural disaccharide scaffold as potent TLR4 agonists for prospective immunotherapeutics and adjuvants. (2022) Chem. Eur. J. (28), e202200547. doi:10.1002/chem.202200547

Heine, H., Adanitsch, F., Peternelj, T. T., Haegman, M., Kasper, C., Ittig, S., Beyaert, R., Jerala, R., Zamyatina, A. Tailored modulation of cellular pro-inflammatory responses with disaccharide lipid A mimetics. (2021) Front. Immunol. 12, Article 631797. doi: 10.3389/fimmu.2021.631797

Schijns, V., Majhen, D., van der Ley, P., Thakur, A., Summerfield, A., Berisio, R., Nativi, C., Fernández-Tejada, A., Alvarez-Dominguez, C., Gizurarson, S., Zamyatina, A., Molinaro, A., Rosano, C., Jakopin, Ž., Gursel, I., McClean, S. Rational vaccine design in times of emerging diseases: the critical choices of immunological correlates of protection, vaccine antigen and immunomodulation. (2021) Pharmaceutics 13, 501. doi: 10.3390/pharmaceutics13040501

Zamyatina, A., Heine, H. Lipopolysaccharide recognition in the crossroads of TLR4 and caspase-4/11 mediated inflammatory pathways. (2020) Front. Immunol. 11, Article 585146. doi: 10.3389/fimmu.2020.585146

Zamyatina, A., and Strobl, S. Synthesis of bioactive lipid A and analogs (2020) Recent Trends in Carbohydrate Chemistry (Rauter, A. P., Christensen, B. E., Somsák, L., Kosma, P., and Adamo, R., Eds.), pp 51-102, Elsevier. doi: 10.1016/B978-0-12-820954-7.00003-7

Adanitsch, F.; Shi, J.; Shao, F.; Beyaert, R.; Heine, H.; Zamyatina, A.
Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.
(2018) Chem. Science (9), 3957-3963; DOI: 10.1039/C7SC05323A

Zhou, P.; She, Y.; Dong, N.; Li, P.; He, H.; Borio, A.; Wu, Q.; Lu, S.; Ding, X.; Cao, Y.; Xu, Y.; Gao, W.; Dong, M.; Ding, J.; Wang, D. C.; Zamyatina, A.; Shao, F.
Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose.
(2018) Nature  (561), 122-126; DOI: doi.org/10.1038/s41586-018-0433-3

Borio, A.; Holgado, A.; Garate, J. A.; Beyaert, R.; Heine, H.; Zamyatina, A. Disaccharide-based anionic amphiphiles as potent inhibitors of lipopolysaccharide-induced inflammation.
(2018), ChemMedChem, (13), 2317-2331; DOI: 10.1002/cmdc.201800505

Garcia-Weber, D.; Dangeard, A.-S.; Cornil, J.; Thai, L.; Rytter, H.; Zamyatina, A.; Mulard, L.; Arrieumerlou, C.
ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri.
(2018), EMBO Rep, (19), e46943; DOI: 10.15252/embr.201846943

Zamyatina, A.
Aminosugar-based immunomodulator lipid A: synthetic approaches.
(2018), Beilstein J. Org. Chem., 25-53; DOI: 10.3762/bjoc.14.3

Zimmermann, S.; Pfannkuch, L.; Al-Zeer, M. A.; Bartfeld, S.; Koch, M.; Liu, J.; Rechner, C.; Soerensen, M.; Sokolova, O.; Zamyatina, A.; Kosma, P.; Mäurer, A. P.; Glowinski, F.; Pleissner, K. P.; Schmid, M.; Brinkmann, V.; Karlas, A.; Naumann, M.; Rother, M.; Machuy, N.; Meyer, T. F.
ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System.
(2017), Cell Rep. (10), 2384-2395; DOI: 10.1016/j.celrep.2017.08.039

Borio, A.; Kosma, K.; Zamyatina, A.
Chemical synthesis of the innate immune modulator - bacterial D-glycero-β-D-manno-heptose-1,7-bisphosphate (HBP).
(2018), Tett. Lett. (58), 2826-2829; DOI: 10.1016/j.tetlet.2017.06.014

Hollaus, R.; Kosma, K.; Zamyatina, A.
Stereoselective Synthesis of α- and β-L-Ara4N glycosyl H-phosphonates and a neoglycoconjugate comprising glycosyl phosphodiester linked β-L-Ara4N.
(2017). Org. Lett. (19), 78-81; DOI: 10.1021/acs.orglett.6b03358

Garate, J. A.; Stöckl, J.; Fernández-Alonso, M.; Artner, D.; Haegman, M.; Oostenbrink, C.; Jiménez-Barbero, J.; Beyaert, R.; Heine, H.; Kosma, P.; Zamyatina, A.
Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold.
(2015), Innate Immun., (21), 490-503; DOI:10.1177/1753425914550426

Hollaus, R.; Ittig, S.; Hofinger, A.; Haegman, M.; Beyaert, R.; Kosma, K.; Zamyatina, A.
Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-β-L-arabinose and its immunomodulatory potential.
(2015), Chemistry, (21), 4102-4114; DOI: 10.1002/chem.201406058

Adanitsch, F.; Ittig, S.; Stöckl, J.; Oblak, A.; Haegman, M.; Jerala, R.; Beyaert, R.; Kosma, P.; Zamyatina, A.
Development of αGlcN(1↔1)αMan-based Lipid A mimetics as a novel class of potent Toll-like Receptor 4 agonists.
(2014), J. Med. Chem. (19), 8056-8071; DOI: 10.1021/jm500946r

Artner, D.; Oblak, A.; Ittig, S.; Garate, J. A.; Horvat, S.; Arrieumerlou, C. ; Hofinger, A.; Oostenbrink, C.; Jerala, R.; Kosma, P.; Zamyatina, A.
Conformationally constrained Lipid A mimetics for exploration of structural basis of TLR4/MD-2 activation by lipopolysaccharide.
(2013), ACS Chem. Biol. (12), 2423-2432.