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Research project (§ 26 & § 27)
Duration : 2020-10-01 - 2022-09-30

Being a fundamental feature of yeast metabolism, the Crabtree phenotype describes whether a yeast can perform aerobic fermentation at a higher glycolytic flux. It provides Crabtree positive yeasts evolutionary benefits to outcompete other microorganism as these yeasts are able to consume glucose faster and produce ethanol in sugar rich environments. It requires a complex deregulation of glycolysis and fermentation pathways as well as TCA cycle. A number of events were found to be contributed to the emergence of the Crabtree phenotype: whole genome duplication (WGD), rewiring of the transcriptional network, horizontal transfer of the URA1 gene, loss of respiratory complex I (CI), and duplication of hexose transporter genes; but the initial molecular mechanisms that promoted its evolution remains unresolved. Hypothesis: A single mutation of CRA1 of K. phaffii was the first step towards evolving a strong Crabtree positive phenotype by providing evolutionary benefits in the microbial populations without requiring more complex rewiring of the carbon metabolism.
Research project (§ 26 & § 27)
Duration : 2019-04-01 - 2021-01-31

One of the main challenges of the next century is the CO2 emission reduction in a sustainable way in order to mitigate climate change. Further, the increasing food demand of the growing world population has to be covered under preservation of the diversity of natural ecosystems. Our aim is to tap CO2 as a sustainable resource in order to provide a commercial solution for the climate issue. With a novel yeast strain, CO2 can be converted into high-value biomass which is used as an animal feed additive, without using agricultural area.
Research project (§ 26 & § 27)
Duration : 2019-01-02 - 2020-12-31

The biological information derived from the microbiome can help to answer crucial questions that may arise when dealing with valuable objects. A microbial pedigree can help to: • certificate the authenticity of an object, • to identify the biological material and microbial species of an artefact, • to get insights into the geographical origin of an artefact, • to get insights into the travel history of an object and into the storage conditions, • to group objects of unknown origin, • to decipher the usage of an object. The samples for performing microbial pedigrees will be provided by the Istituto Centrale per il Restauro e la Conservazione del Patrimonio Archivistico e Librario. Up to 6 cotton swabs or membrane samples will be taken from each object and will be pooled into one microbial pedigree analysis.

Supervised Theses and Dissertations