Core Facility Biomolecular & Cellular Analysis

The BOKU Core Facility for Biomolecular & Cellular Analysis (BMCA) is a state-of-the-art analytical laboratory providing access to advanced instrumentation and expert knowledge. It specialises in three key areas: biomolecular analysis, including the characterization of proteins and particles as well as the study of biomolecular interactions; cellular analysis using flow cytometry for cell characterization and sorting; and structural analysis, encompassing X-ray crystallography and BioSAXS, supported by a comprehensive infrastructure for sample preparation, data collection, and data processing.

Beyond providing access to advanced instrumentation, we support researchers throughout the entire experimental process, from optimised sample preparation to data generation. Our trained-user mode offers hands-on instruction in specialised techniques, combined with expert guidance on experimental design and setup.

For researchers seeking comprehensive support, our full-service mode includes sample measurements performed by experienced staff, along with detailed experimental reports to ensure reliable, high-quality results.

Biomolecular analysis

A strong focus lies on the investigation and characterization of various biomolecular interactions. To support this, we are equipped with:

To characterize biomolecules in terms of molecular weight, thermal stability, thermodynamics of unfolding, aggregation behaviour, size and zeta potential, the following equipment is available:

For purification of protein samples, you can book our:

Cellular analysis

As our name suggests, we also provide techniques for analyzing cells and cellular components through flow cytometry. We are equipped with two analytical flow cytometry machines as well as one FACS (Fluorescence-Activated Cell Sorting) instrument, enabling precise and efficient cell sorting for applications such as functional assays, single-cell analysis, and purification:

Structural analysis

We offer comprehensive infrastructure for X-ray crystallography and BioSAXS. Our services include:

  • Crystallisation setup and optimisation, and crystal handling (harvesting, freezing, and storage)
  • Coordination of sample or crystal shipment and data collection at synchrotron facilities
  • Data processing and structural analysis

For this, we are equipped with:

We are a member of ARBRE-MOBIEU.

We work closely together with the Core Facility Biomolecular Interactions and Crystallization at CEITEC, Brno, and the
ProTech Facility at the Vienna BioCenter Core Facilities (VBCF)

Irene Schaffner, PhD
Head of BOKU Core Facility Biomolecular & Cellular Analysis
Elisabeth Laurent, PhD
Deputy Head of BOKU Core Facility Biomolecular & Cellular Analysis. Scientist responsible for flow cytometry & protein crystallography.
Georg Schütz, PhD
Scientist responsible for biomolecular analysis & protein crystallography
Arthur Sedivy, DI
Scientist specialised on biophysical characterization of biomolecules
Karin Kohlweiss, BSc
Technician with focus on flow cytometry
Jakob Wallner, BSc
Technician specialised on biophysical characterization of biomolecules

Management

Head

Dipl.-Ing.Dr.
 Irene Schaffner
Deputy

Dipl.-Ing. Ph.D.
 Elisabeth Laurent

Addresses & Contact

Core Facility Biomolecular & Cellular Analysis

Simon-Zeisel-Haus
Muthgasse 11
1190 Wien

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