Impromptu seminar by Toshiki Kameyama
"Cancer-specific aberrant mRNA re-splicing and its repressors: What are the splicing termination mechanisms destroyed in cancer cells?"
(Fujita Health University, Japan)
"We have recently discovered the cancer-specific aberrant splicing that occurs through re-splicing in the mature spliced mRNAs. In normal cells, spliced mRNA must export to the cytoplasm to serve as a template for the protein biosynthesis. However, such mature mRNA is spliced again and generates aberrant truncated mRNA in cancer cells. This finding implicates the control mechanism to prevent deleterious extra mRNA splicing that must operate in normal cells. We are currently identifying repressor candidates of mRNA re-splicing."
Toshiki Kameyama is an Assistant Professor at the Division of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health University, Japan. His research focuses on aberrant splicing in cancer and transcriptional and post-transcriptional regulation of gene expression in the nervous system development and in neurological diseases.
27. February 2019, 11:00 am
Seminarraum Angewandte Genetik (MUG2-04/54)
Muthgasse 18, 1190 Wien